Your browser doesn't support javascript.
Antiphospholipid antibodies and vitamin D deficiency in COVID-19 infection with and without venous or arterial thrombosis: A pilot case-control study.
Shah, Ruchi; Mohammed, Yaqub Nadeem; Koehler, Tracy J; Kaur, Jasmeet; Toufeili, Margarita; Pulipati, Priyanjali; Alqaysi, Ahmed; Khan, Ali; Khalid, Mahrukh; Lee, Yi; Dhillon, Parveen; Dan, Anna Thao; Kumar, Nicholas; Bowen, Monica; Sule, Anupam A; Krishnamoorthy, Geetha.
  • Shah R; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
  • Mohammed YN; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
  • Koehler TJ; Mercy Health Muskegon, Muskegon, Michigan, United States of America.
  • Kaur J; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
  • Toufeili M; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
  • Pulipati P; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
  • Alqaysi A; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
  • Khan A; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
  • Khalid M; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
  • Lee Y; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
  • Dhillon P; Ross University School of Medicine, Miramar, Florida, United States of America.
  • Dan AT; Ross University School of Medicine, Miramar, Florida, United States of America.
  • Kumar N; Ross University School of Medicine, Miramar, Florida, United States of America.
  • Bowen M; Mercy Health Muskegon, Muskegon, Michigan, United States of America.
  • Sule AA; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
  • Krishnamoorthy G; Department of Internal Medicine, Saint Joseph Mercy Oakland, Pontiac, Michigan, United States of America.
PLoS One ; 17(7): e0269466, 2022.
Article in English | MEDLINE | ID: covidwho-1933333
ABSTRACT

BACKGROUND:

Coronavirus disease-2019 (COVID-19) is associated with thromboembolism. Antiphospholipid antibody (APLa) formation is one of the mechanisms. Vitamin D deficiency has been associated with thrombosis in antiphospholipid antibody syndrome.

OBJECTIVE:

Measure APLa and vitamin D in hospitalized COVID-19 patients with and without thrombosis to evaluate if thromboembolism is associated with concomitant APLa and vitamin D deficiency.

METHODS:

Case-control study. Hospitalized COVID-19 patients with a thromboembolic event (ischemic stroke, myocardial infarction, deep venous thrombosis/pulmonary embolism, Cases n = 20). Controls (n = 20) Age, sex-matched without thromboembolic events. Patients with autoimmune disorders, antiphospholipid antibody syndrome, thrombophilia, anticoagulation therapy, prior thromboembolism, chronic kidney disease 3b, 4, end-stage renal disease, and malignancy were excluded. Given the limited current literature on the role of concomitant antiphospholipid antibodies and vitamin D deficiency in causing venous and/or arterial thrombosis in hospitalized COVID-19 patients, we enrolled 20 patients in each arm. Anti-cardiolipin IgG/IgM, beta-2 glycoprotein-1 IgG/IgM, lupus anticoagulant and vitamin D levels were measured in both groups.

RESULTS:

Cases were 5.7 times more likely to be vitamin D deficient (OR5.7, 95% CI1.3-25.6) and 7.4 times more likely to have any one APLa (OR7.4, 95% CI 1.6-49.5) while accounting for the effects of sex. Patients with both APLa and vitamin D deficiency had significantly more thrombosis compared to patients who were antibody positive without vitamin D deficiency (100% vs 47.4%; p = 0.01).

CONCLUSIONS:

Thrombosis in COVID-19 was associated with concomitant APLa and vitamin D deficiency. Future studies in COVID-19 should assess the role of vitamin D in reducing thrombosis.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Thromboembolism / Thrombosis / Vitamin D Deficiency / Antiphospholipid Syndrome / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0269466

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Thromboembolism / Thrombosis / Vitamin D Deficiency / Antiphospholipid Syndrome / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0269466