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Induction of T Cell Senescence by Cytokine Induced Bystander Activation.
Abbas, Attiya A; Akbar, Arne N.
  • Abbas AA; Division of Medicine, University College London, London, United Kingdom.
  • Akbar AN; Division of Medicine, University College London, London, United Kingdom.
Front Aging ; 2: 714239, 2021.
Article in English | MEDLINE | ID: covidwho-1933921
ABSTRACT
As people around the world continue to live longer, maintaining a good quality of life is of increasing importance. The COVID-19 pandemic revealed that the elderly are disproportionally vulnerable to infectious diseases and Immunosenescence plays a critical role in that. An ageing immune system influences the conventional activity of T cells which are at the forefront of eliminating harmful foreign antigens. With ageing, unconventional end-stage T cells, that exhibit a senescent phenotype, amass. These senescent T cells deviate from T cell receptor (TCR) signaling toward natural killer (NK) activity. The transition toward innate immune cell function from these adaptor T cells impacts antigen specificity, contributing to increased susceptibility of infection in the elderly. The mechanism by which senescent T cells arise remains largely unclear however in this review we investigate the part that bystander activation plays in driving the change in function of T cells with age. Cytokine-induced bystander activation may offer a plausible explanation for the induction of NK-like activity and senescence in T cells. Further understanding of these specific NK-like senescent T cells allows us to identify the benefits and detriments of these cells in health and disease which can be utilized or regulated, respectively. This review discusses the dynamic of senescent T cells in adopting NK-like T cells and the implications that has in an infectious disease context, predominately in the elderly.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Aging Year: 2021 Document Type: Article Affiliation country: Fragi.2021.714239

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Aging Year: 2021 Document Type: Article Affiliation country: Fragi.2021.714239