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Multiple Basal Cell Carcinomas in Immunocompetent Patients.
Savoia, Paola; Veronese, Federica; Camillo, Lara; Tarantino, Vanessa; Cremona, Ottavio; Zavattaro, Elisa.
  • Savoia P; Department of Health Sciences, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy.
  • Veronese F; Azienda Ospedaliera Universitaria Maggiore della Carità, c.so Mazzini 18, 28100 Novara, Italy.
  • Camillo L; Department of Health Sciences, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy.
  • Tarantino V; Azienda Ospedaliera Universitaria Maggiore della Carità, c.so Mazzini 18, 28100 Novara, Italy.
  • Cremona O; Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milan, Italy.
  • Zavattaro E; Azienda Ospedaliera Universitaria Maggiore della Carità, c.so Mazzini 18, 28100 Novara, Italy.
Cancers (Basel) ; 14(13)2022 Jun 30.
Article in English | MEDLINE | ID: covidwho-1933984
ABSTRACT

BACKGROUND:

The onset of multiple BCCs is a relatively common condition, not only among patients undergoing chronic treatment with immunosuppressant drugs, but also in the general population, although specific risk factors for immunocompetent patients have not been identified. A putative role of somatic mutations in the hedgehog pathway should be considered.

METHODS:

This study is a retrospective observation of all patients diagnosed and surgically treated for BCCs during 5 years at our Dermatological Division. For these patients, we evaluated clinical and histopathological characteristics and data about possible risk factors for BCC.

RESULTS:

Five-hundred and six patients affected by multiple BCCs, accounting for the 24.2% of the entire sample, have been identified. In these patients, the total number of BCCs was 1516, ranging from 2 to 11. Subjects affected by multiple BCCs were more frequently males, with an older age at diagnosis; multiple BCCs developed mainly on the trunk and were often represented by a nodular histotype. The multivariate analysis highlighted that male gender, older age, nodular BCC, or face involvement at the first diagnosis are risk factors for the development of multiple BCCs.

CONCLUSIONS:

The frequency of multiple BCCs even among the non-immunocompromised population underlines the need to subject patients to a close surveillance program, to allow early diagnosis and treatment of additional cancers.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Cancers14133211

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Cancers14133211