What Inhibits Natural Killers' Performance in Tumour.
Int J Mol Sci
; 23(13)2022 Jun 24.
Article
in English
| MEDLINE | ID: covidwho-1934121
ABSTRACT
Natural killer cells are innate lymphocytes with the ability to lyse tumour cells depending on the balance of their activating and inhibiting receptors. Growing numbers of clinical trials show promising results of NK cell-based immunotherapies. Unlike T cells, NK cells can lyse tumour cells independent of antigen presentation, based simply on their activation and inhibition receptors. Various strategies to improve NK cell-based therapies are being developed, all with one goal to shift the balance to activation. In this review, we discuss the current understanding of ways NK cells can lyse tumour cells and all the inhibitory signals stopping their cytotoxic potential.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Immunotherapy, Adoptive
/
Neoplasms
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Ijms23137030
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