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Impact of COVID-19-related lockdown on retinal disorders treated with intravitreal injections.
Brar, Manpreet; Grewal, Satinder Pal Singh; Grewal, Dilraj S; Sharma, Mansi; Dogra, Mangat Ram.
  • Brar M; Department of Retina, Grewal Eye Institute, Chandigarh, India.
  • Grewal SPS; Department of Ophthalmology, Duke University, Durham, NC, USA.
  • Grewal DS; Department of Retina, Grewal Eye Institute, Chandigarh, India.
  • Sharma M; Department of Retina, Grewal Eye Institute, Chandigarh, India.
  • Dogra MR; Department of Retina, Grewal Eye Institute, Chandigarh, India.
Oman J Ophthalmol ; 15(2): 168-174, 2022.
Article in English | MEDLINE | ID: covidwho-1934428
ABSTRACT

PURPOSE:

To study functional changes in vision and morphological changes on optical coherence tomography (OCT) scans in patients where intravitreal therapy (IVT) with injections has been delayed due to COVID-19 pandemic lockdown.

METHODS:

Retrospective cross-sectional study included 77 eyes with the diagnosis of exudative age-related macular degeneration (eAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO), regularly receiving IVT with anti-vascular endothelial growth factor (Anti-VEGF) injections or dexamethasone implant and were not able to receive the injections as intended due to lockdown. Best-corrected visual acuity (BCVA), central foveal thickness (CFT), and qualitative morphological features on OCT were analyzed pre- and post-therapy break off.

RESULTS:

The mean duration of IVT break-off was 57 days. Mean BCVA logarithm of minimum angle of resolution (logMAR) worsened from 0.33 (20/42) to 0.35 (40/44) (P = 0.02) and mean CFT increased from 297.90 µm to 402.16 µm (P < 0.01), from pretherapy break-off to return visit. Worsening of the visual acuity was seen across all the three disease cohorts, significantly more in the eyes with eAMD.

CONCLUSION:

Marginal decline in the visual acuity and worsening of the OCT features were observed as a result of delay in the IVT injections of DME, eAMD and RVO patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Language: English Journal: Oman J Ophthalmol Year: 2022 Document Type: Article Affiliation country: Ojo.ojo_74_21

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Language: English Journal: Oman J Ophthalmol Year: 2022 Document Type: Article Affiliation country: Ojo.ojo_74_21