The first report of myocarditis followed by AstraZeneca vaccination in Iran
Chronic Diseases Journal
; 10(2):117-120, 2022.
Article
in English
| CAB Abstracts | ID: covidwho-1934871
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) is an emerging disease caused by the coronavirus. The initiation of vaccination significantly reduced the incidence and mortality of these patients. Some studies reported myocarditis as a rare complication after messenger ribonucleic acid (mRNA)-based vaccines (such as Pfizer). CASE REPORT The patient was a 26-year-old man without any history of the underlying disease with typical chest pain which spread to the back and left arm;he was diagnosed with myocarditis after the second dose of the AstraZeneca vaccine. The mechanism of myocarditis after AstraZeneca is not known precisely. It seems to be due to the AstraZeneca vaccine using adenovirus as a vector of the spike (S) protein of the virus, and it causes the production of antibodies in the body, while adenovirus can be one of the causes of myocarditis. On the other hand, it may be due to spike protein-mediated toxicity, which causes an inflammatory reaction such as myocarditis after the virus protein enters the bloodstream and eventually accumulates in various tissues, including the heart.CONCLUSION:
Myocarditis is a rare complication of the AstraZeneca vaccine, and this study could not recommend neglecting this vaccine.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Host Resistance and Immunity [HH600]; Pharmacology [VV730]; human diseases; viral diseases; case reports; vaccines; immunization; vaccination; disease prevention; health protection; coronavirus disease 2019; antibodies; complications; heart; immune response; inflammation; mortality; thorax; myocardium; immune sensitization; man; Severe acute respiratory syndrome coronavirus 2; Iran; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; high Human Development Index countries; lower-middle income countries; Middle East; West Asia; Asia; ChAdOx1 nCoV-19; SARS-CoV-2; viral infections; immunity reactions; immunological reactions; death rate; cardiac muscle; heart muscle
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Topics:
Vaccines
Language:
English
Journal:
Chronic Diseases Journal
Year:
2022
Document Type:
Article
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