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Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic.
Bezruk, Volodymyr Volodymyrovych; Shkrobanets, Igor Dmytrovych; Godovanets, Oleksii Serhiiovych; Buriak, Oleksandr Hryhorovych; Pervozvanska, Olga Ivanivna; Honcharuk, Ludmila Mykhailivna; Voytkevich, Nina Ivanivna; Makarova, Olena Victorivna; Yurkiv, Oksana Ivanivna; Sheremet, Michael Ivanovych; Hresko, Mykhailo Mykhailovich; Velia, Mariya Ivanivna; Yurniuk, Svyatoslava Vasylivna; Hresko, Maryna Dmytrivna; Bulyk, Tetiana Sergiivna; Rynzhuk, Larysa Vasylyvna.
  • Bezruk VV; Department of Pediatrics, Neonatology and Perinatology Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Shkrobanets ID; Department of Medical and Organizational Management, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine.
  • Godovanets OS; Department of Pediatrics, Neonatology and Perinatology Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Buriak OH; Department of Pediatrics, Neonatology and Perinatology Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Pervozvanska OI; Department of Nephrology, Pediatric Clinical Hospital, Chernivtsi, Ukraine.
  • Honcharuk LM; Department of Internal Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Voytkevich NI; Department of Foreign Languages, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Makarova OV; Department of Care for Patients and Higher Nursing Education, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Yurkiv OI; Department of Care for Patients and Higher Nursing Education, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Sheremet MI; Surgery Department No.1, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Hresko MM; Surgery Department No.1, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Velia MI; Department of Pharmacy, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Yurniuk SV; Department of Pharmacy, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Hresko MD; Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Bulyk TS; Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine.
  • Rynzhuk LV; Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine.
J Med Life ; 15(5): 617-619, 2022 May.
Article in English | MEDLINE | ID: covidwho-1934915
ABSTRACT
Urinary tract infections (UTIs) remain an urgent issue in clinical pediatrics. Empirical selection of antibacterial therapy becomes more complicated, and antibacterial drug indication is not always clinically substantiated. This study aimed to compare the antibacterial susceptibility pattern of the main group of urinary tract infectious agents from 2009-2016 with intermediate results from 2020-2021, during the COVID-19 pandemic, among children in the Chernivtsi region. Urine samples were collected from 3089 children (0-17 years old) treated at the health care institutions in the Chernivtsi region (2009-2016). The clinical-laboratory examination of 177 children (0-17 years old) was carried out from 2020 to 2021. The children received specialized medical care at the Department of Nephrology. Preliminary data of regional monitoring (2020-2021) are not considerably different from the previous regional susceptibility of antibiotics to penicillin (p<0.01), ІІ-ІІІ generation cephalosporin (p<0.01); an increased resistance to levofloxacin (χ2=4,338; p<0.01), tetracycline - χ2=7,277; p<0.01; doxycycline - χ2=5,309; p<0.01) and imipenem - χ2=5,594; p<0.01). The data obtained did not explain an increased resistance to fluoroquinolones completely (ofloxacin, pefloxacin, ciprofloxacin), except for levofloxacin (χ2=4,338; p<0.01). A reliable difference of susceptibility of tetracycline group was registered (tetracycline - χ2=7,277; p<0.01; doxycycline - χ2=5,309; p<0.01). Furthermore, there was a regional increase in some UTI-pathogen strains resistant to carbapenems (imipenem - χ2=5,594; p<0.01). The use of antibiotics from the group of penicillins and II-III generation cephalosporins as the starting antibacterial therapy for STIs during the COVID-19 pandemic should be justified. A regional increase (2020-2021) of some uropathogenic strains resistant to carbapenems administered to treat severe bacterial infections requires their exclusively designated purpose in everyday pediatric practical work.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Urinary Tract / Urinary Tract Infections / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Humans / Infant / Infant, Newborn Language: English Journal: J Med Life Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Jml-2021-0293

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Urinary Tract / Urinary Tract Infections / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Humans / Infant / Infant, Newborn Language: English Journal: J Med Life Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Jml-2021-0293