Assessing of Humoral Immunity to SARS-COV-2 in Residents of Orenburg During the Epidemic Period

ABSTRACT

Relevance. The formation of humoral immunity is one of the most important manifestations of the protective mechanism against an infectious disease. The formation of antibodies with neutralizing activity is a key factor in preventing infection. Aims. Analysis of the esults of an ELISA study for the presence of IgM and IgG antibodies to the causative agent of a new coronavirus infection (COVID-19) in the population of the Central Orenburg region. Materials and methods. Immunoassay of blood serum for the presence of IgM and IgG antibodies using ELISA test by Vectro-Best (Novosibirsk, Russia). Results and discussion. The analysis revealed the presence of more than half of the cases of sero conversion among the examined individuals. The most surveyed was the group aged 21 to 65 years. The most typical humoral immune response to SARS-CoV-2 has been established, and the age-related characteristics of its formation have been determined. The dependence of the positivity coefficient on the age of the patients was revealed. Conclusions. According to the results of the study, the formed humoral (collective) immunity to the SARS-CoV-2 virus was registered in more than half of the studied sample. © Pankov AS et al.