Dipyridamole does not have any additive effect on the prevention of COVID-19 coagulopathy
American Journal of Blood Research
; 12(2):54-59, 2022.
Article
in English
| EMBASE | ID: covidwho-1935125
ABSTRACT
Objective:
Severe acute respiratory syndrome (SARS) coronavirus 2 (SaRS-Cov-2) associated respiratory disease (COVID-19), announced as a pandemic, is a multisystem syndrome. SARS-CoV-2 directly infects and damages vascular endothelial cells, which leads to microvascular dysfunction and promotes a procoagulant state. Dipyridamole (DP) acts as a reversible phosphodiesterase inhibitor and is used mainly as an antiplatelet agent. It is hypothetised that it has possible activities in COVID-19. Design andMethodology:
We report our retrospective, real-world results of DP added to low-molecular weight heparin (LMWH) in the treatment of 462 clinically diagnosed and hospitalized COVID-19 patients. We compared anticoagulation with and without DP addition with no administration of anticoagulation in the same time frame. The primary outcome was proven or highly suspected coagulopathy within 30 days of hospitalization.Results:
Definitive coagulopathy has been diagnosed in 3 (3.5%) of 85 LMWH administered patients and 7 (2.13%) of 328 DP + LMWH received patients (P=0.456). Five cases with definitive coagulopathy were not initiated any anticoagulation at the time of the event. The multivariate analysis showed that DP addition to the anticoagulant approach did not have any impact on the risk of demonstrated coagulopathy and highly-suspected coagulopathy.Conclusion:
We think that our clinical experience is valuable in showing the real-life results of DP + LMWH treatment in COVID-19. This approach did not affect the coagulopathy rate. Our data did also not document an additive effect of DP in the COVID-19 outcome. Prospective controlled trials would give more convincing results regarding the role of DP in COVID-19 endothelial dysfunction and clinical outcome.
anticoagulant agent; D dimer; dipyridamole; enoxaparin; favipiravir; low molecular weight heparin; additive effect; adult; anticoagulation; article; blood biochemistry; computer assisted tomography; COVID-19-associated coagulopathy; disseminated intravascular clotting; female; hospitalization; human; human cell; macrophage activation syndrome; major clinical study; male; outcome assessment; oxygen saturation; pneumonia; prophylaxis; real time polymerase chain reaction; retrospective study; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; vascular disease
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
Language:
English
Journal:
American Journal of Blood Research
Year:
2022
Document Type:
Article
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