PATIENT REPORTED OUTCOMES FOLLOWING SARS-COV-2 VACCINATION IN PATIENTS WITH CANCER
Supportive Care in Cancer
; 30:S19-S20, 2022.
Article
in English
| EMBASE | ID: covidwho-1935779
ABSTRACT
Introduction Limited data exist regarding safety of COVID19 vaccinations for patients with cancer. Methods SerOzNET (ACTRN12621001004853) is a large prospective study of adults and children with cancer undergoing Sars-CoV-2 vaccination. Participants undertake a validated hesitancy survey at enrolment (Oxford COVID-19 Vaccine Confidence and Complacency Scale) and prior to the 3rd vaccine dose. Quality of life is assessed with serial EORTC QLQ-C30 (adults) or PedsQL (children). Patient- reported vaccine toxicity is assessed by patient-reported CTCAE items for common vaccine related AEs and patient-reported impact of vaccination on cancer treatment . Medically ascertained vaccine toxicity is assessed by study investigators one month after the 3rd vaccination dose. Results Five hundred and four participants have been enrolled (403 adults (80%) and 101 children (20%)). Baseline hesitancy surveys have been completed by 349 adults (87%), 58 parents (57%) and 51/86 eligible children (59%). Patient toxicity surveys have been returned post dose 1 for 445 (88%), post dose 2 for 417 (83%) and post dose 3 for 280 (56%). Incidence of any AEs was high (77-100% depending on age and dose), however the incidence of severe AEs (patient reported) was low (0-10% depending on age and dose). Interruptions to cancer treatment after vaccination were uncommon (2-12%). Conclusions Data to date are reassuring that severe adverse events and interruptions to cancer therapy post COVID19 vaccination are uncommon.
vaccine; adult; adverse drug reaction; cancer therapy; child; conference abstract; coronavirus disease 2019; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30; female; human; incidence; major clinical study; male; nonhuman; outcome assessment; patient-reported outcome; prospective study; quality of life; Severe acute respiratory syndrome coronavirus 2; side effect; vaccination
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Vaccines
Language:
English
Journal:
Supportive Care in Cancer
Year:
2022
Document Type:
Article
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