RACIAL DISPARITIES IN ADULT CANCER PATIENTS WITH ACUTE KIDNEY INJURY (AKI) AND CORONAVIRUS 2019 (COVID-19) INFECTION

ABSTRACT

Introduction COVID-19 infection is associated with a higher incidence of medical complications including AKI. It is not well known if racial differences are associated with worse outcomes. Methods All patient data from March 2020 through February 2021 were aggregated and analyzed as part of the D3CODE protocol at MD Anderson. Cohort (1) positive COVID-19 test (2) baseline eGFR >60 ml/min/ 1.73m2 within 30 days prior to COVID infection. AKI defined by increased creatinine ≥0.3 within 30 days after infection. Kaplan-Meier analysis was used for survival estimates. Multivariable Cox Proportional Hazard model regression analysis was used for hazard ratios. Results 635 patients with Covid-19 infection were identified. 124 (19.5%) developed AKI. AKI patients were more likely to have pneumonia (63.7% vs 37%, p<0.001), cardiac arrhythmias (39.5% vs 20.7%, p<0.001) myocardial infarction (15.3% vs 8.8%, p=0.046), require dialysis (2.4% vs 0.2%, p=0.025), mechanical ventilation (16.1% vs 1.8%, p<0.001), ICU admission (43.5% vs 11.5%, p<0.001) within 30 days, and had a higher mortality at 90 days of admission (20.2% vs 3.7%, p<0.001). Hispanic or Latino ethnicity (HR 56.6 CI 2.12-1510.57 p=0.016) vs White (HR 0.35 CI 0.02-6.02 p=0.47) was an independent risk factor associated with worse outcomes Conclusions Being Hispanic is associated with worse clinical outcomes in cancer patients with COVID-19 infection and AKI. Further studies are needed to address these disparities.