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Genetic characteristics of human coronavirus HKU1 in mainland China during 2018.
Chen, Xiangpeng; Zhu, Yun; Li, Qi; Lu, Gen; Li, Changchong; Jin, Rong; Li, Lei; Xu, Baoping; Gao, Liwei; Yin, Ju; Xie, Zhengde.
  • Chen X; Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Labora
  • Zhu Y; Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Labora
  • Li Q; Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Labora
  • Lu G; Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China.
  • Li C; The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.
  • Jin R; Guiyang Maternal and Child Health Hospital, Guiyang, 550003, China.
  • Li L; Yinchuan Maternal and Child Health Care Hospital, Yinchuan, 750001, China.
  • Xu B; Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 10045, China.
  • Gao L; Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 10045, China.
  • Yin J; Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 10045, China.
  • Xie Z; Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Labora
Arch Virol ; 167(11): 2173-2180, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-1935818
ABSTRACT
Human coronavirus HKU1 (HCoV-HKU1) is a pathogen that causes acute respiratory tract infections in children and circulates worldwide. To investigate the molecular characteristics and genetic diversity of HCoV-HKU1 in China, a molecular epidemiological analysis based on complete genome sequences was performed. A total of 68 endemic-HCoV-positive samples were identified from 1358 enrolled patients during 2018, including four HCoV-229E, nine HCoV-OC43, 24 HCoV-NL63, and 31 HCoV-HKU1. The detection rate of endemic HCoVs was 5.01% during 2018, while for HCoV-HKU1, it was 2.28%. Eight complete genomic sequences of HCoV-HKU1 were obtained and compared to 41 reference genome sequences corresponding to genotypes A, B, and C, obtained from the GenBank databank. Of the eight HKU1 sequences, four belonged to genotype A and four belonged to genotype B. No genotype C strains were detected in this study. For genotype A, 18 variations in the S protein with respect to the reference sequence were present in more than 5% of the sequences, whereas for genotype B, this number was 25. Most of the amino acid changes occurred in the S1 subunit. No amino acid substitutions were found in the sites that are essential for interaction with neutralizing antibodies, while a 510T amino acid insertion was found in almost one third of genotype B sequences. About 82-83, 85-89, and 88-89 predicted N-glycosylation sites and 7-13, 6-8, and 9 predicted O-glycosylation sites were found among the sequences of genotype A, B, and C, respectively. Six conserved O-glycosylation sites were present in all of the genotype A sequences. Only genotype A and B strains were detected after 2005. The S protein exhibited relatively high diversity, with most of the amino acid changes occurring in the S1 subunit.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Coronavirus Infections / Coronavirus OC43, Human Type of study: Observational study / Prognostic study Limits: Child / Humans Country/Region as subject: Asia Language: English Journal: Arch Virol Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Coronavirus Infections / Coronavirus OC43, Human Type of study: Observational study / Prognostic study Limits: Child / Humans Country/Region as subject: Asia Language: English Journal: Arch Virol Year: 2022 Document Type: Article