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Flavivirus-host interactions: an expanding network of proviral and antiviral factors.
Schneider, William M; Hoffmann, Hans-Heinrich.
  • Schneider WM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Electronic address: wschneider@rockefeller.edu.
  • Hoffmann HH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Electronic address: hhoffmann@rockefeller.edu.
Curr Opin Virol ; 52: 71-77, 2022 02.
Article in English | MEDLINE | ID: covidwho-1936243
ABSTRACT
Flaviviruses are zoonotic pathogens transmitted by the bite of infected mosquitos and ticks and represent a constant burden to human health. Here we review recent literature aimed at uncovering how flaviviruses interact with the cells that they infect. A better understanding of these interactions may ultimately lead to novel therapeutic targets. We highlight several studies that employed low-biased methods to discover new protein-protein, protein-RNA, and genetic interactions, and spotlight recent work characterizing the host protein, TMEM41B, which has been shown to be critical for infection by diverse flaviviruses and coronaviruses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Flavivirus Infections / Flavivirus Limits: Animals / Humans Language: English Journal: Curr Opin Virol Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Flavivirus Infections / Flavivirus Limits: Animals / Humans Language: English Journal: Curr Opin Virol Year: 2022 Document Type: Article