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Evaluation of independent self-collected blood specimens for COVID-19 antibody detection among the US veteran population.
Mohammed, Tseli; Brewer, Jessica V V; Pyatt, Mary; Whitbourne, Stacey B; Gaziano, J Michael; Edson, Connor; Holodniy, Mark.
  • Mohammed T; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA. Electronic address: Tseli.Mohammed@va.gov.
  • Brewer JVV; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Pyatt M; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Whitbourne SB; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Boston, MA, USA.
  • Gaziano JM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Boston, MA, USA.
  • Edson C; VHA Public Health Reference Laboratory (PHRL), Palo Alto, CA, USA.
  • Holodniy M; VHA Public Health Reference Laboratory (PHRL), Palo Alto, CA, USA; Department of Medicine, Stanford University, Stanford, CA, USA.
Diagn Microbiol Infect Dis ; 104(2): 115770, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-1936297
ABSTRACT
Feasibility of home blood sample collection methods for the presence of SARS-CoV-2 antibodies from VA Million Veteran Program (MVP) participants was tested to determine COVID-19 infection or vaccination status. Participants (n = 312) were randomly assigned to self-collect blood specimens using the Neoteryx Mitra Clamshell (n = 136) or Tasso-SST (n = 176) and asked to rate their experience. Mitra tip blood was eluted and Tasso tubes were centrifuged. All samples were stored at -80 °C until tested with InBios SCoV-2 Detect™ IgG ELISA, BioRad Platelia SARS-CoV-2 Total Ab Assay, Abbott SARS-CoV-2 IgG and AdviseDx SARS-CoV-2 IgG II assays. Participants rated both devices equally. The Abbott assay had the highest sensitivity (87% Mitra, 98% Tasso-SST) for detecting known COVID infection and/or vaccination. The InBios assay with Tasso-SST had the best sensitivity (97%) and specificity (80%) for detecting known COVID-19 infection and/or vaccination. Veterans successfully collected their own specimens with no strong preference for either device.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Veterans / COVID-19 Type of study: Diagnostic study / Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Diagn Microbiol Infect Dis Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Veterans / COVID-19 Type of study: Diagnostic study / Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Diagn Microbiol Infect Dis Year: 2022 Document Type: Article