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Charge-transfer chemistry of two corticosteroids used adjunctively to treat COVID-19. Part II: The CT reaction of hydrocortisone and dexamethasone donors with TCNQ and fluoranil acceptors in five organic solvents.
Refat, Moamen S; Albogami, Bander; Adam, Abdel Majid A; Saad, Hosam A; Alsuhaibani, Amnah Mohammed; Miyan, Lal; Hegab, Mohamed S.
  • Refat MS; Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Albogami B; Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Adam AMA; Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Saad HA; Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Alsuhaibani AM; Department of Physical Sport Science, College of Education, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
  • Miyan L; Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh 202002(UP), India.
  • Hegab MS; Deanship of Supportive Studies (D.S.S.), Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
J Mol Liq ; 363: 119878, 2022 Oct 01.
Article in English | MEDLINE | ID: covidwho-1937005
ABSTRACT
Hydrocortisone (termed as D1) and dexamethasone (termed as D2) are corticosteroids currently used to treat COVID-19. COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Exploring additional chemical properties of drugs used in the treatment protocols for COVID-19 could help scientists alike improve these treatment protocols and potentially even the vaccines (i.e., Janssen, Moderna, AstraZeneca, Pfizer-BioNTech). In this work, the charge-transfer (CT) properties of these two corticosteroids (D1 and D2) with two universal acceptors 7,8,8-tetracyanoquinodimethane (termed as TCNQ) and fluoranil (termed as TFQ) in five different solvents were investigated. The examined solvents were MeOH, EtOH, MeCN, CH2Cl2, and CHCl3. The CT interactions formed stable corticosteroid CT complexes in all examined solvents. Several spectroscopic parameters were derived, and the oscillator strength (f) and transition dipole moment (µe.g. ) values revealed that the interaction between the investigated corticosteroids with TCNQ acceptor is much stronger than their interaction with TFQ acceptor. The CT interactions were proposed to process via n â†’ π* transition.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: J Mol Liq Year: 2022 Document Type: Article Affiliation country: J.molliq.2022.119878

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: J Mol Liq Year: 2022 Document Type: Article Affiliation country: J.molliq.2022.119878