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The placental pathology in Coronavirus disease 2019 infected mothers and its impact on pregnancy outcome.
Joshi, Bharti; Chandi, Anadeep; Srinivasan, Radhika; Saini, Shiv Sajan; Prasad, G R V; Puri, G D; Bhalla, Ashish; Suri, Vanita; Bagga, Rashmi.
  • Joshi B; Department of Obstetrics and Gynecology, PGIMER, Nehru Block, Sector 12, Chandigarh, 160012, India. Electronic address: drbhartijoshi09@gmail.com.
  • Chandi A; Department of Obstetrics and Gynecology, PGIMER, Nehru Block, Sector 12, Chandigarh, 160012, India. Electronic address: ana.chandi@gmail.com.
  • Srinivasan R; Department of Cytology & Gynecological Pathology, PGIMER, Research Block A, Sector 12, Chandigarh, 160012, India. Electronic address: drsradhika@gmail.com.
  • Saini SS; Division of Neonatology, Department of Pediatrics Medicine, PGIMER, Nehru Block, Sector 12, Chandigarh, 160012, India. Electronic address: sajansaini1@gmail.com.
  • Prasad GRV; Department of Obstetrics and Gynecology, PGIMER, Nehru Block, Sector 12, Chandigarh, 160012, India. Electronic address: prasad.grv@pgimer.edu.in.
  • Puri GD; Department of Anaesthesia, PGIMER, Kairon Block, Chandigarh, 160012, India. Electronic address: puri.gd@pgimer.edu.in.
  • Bhalla A; Department of Internal Medicine, PGIMER, Chandigarh, 160012, India. Electronic address: bhalla.ashish@pgimer.edu.in.
  • Suri V; Department of Obstetrics and Gynecology, PGIMER, Nehru Block, Sector 12, Chandigarh, 160012, India. Electronic address: surivanita@yahoo.co.in.
  • Bagga R; Department of Obstetrics and Gynecology, PGIMER, Nehru Block, Sector 12, Chandigarh, 160012, India. Electronic address: bagga.rashmi@pgimer.edu.in.
Placenta ; 127: 1-7, 2022 09.
Article in English | MEDLINE | ID: covidwho-1937084
ABSTRACT

INTRODUCTION:

This study aims at observing placental pathologies in COVID-19 infected women, and analyzing its impact on pregnancy outcome.

METHOD:

This is a descriptive-analytical study done at a tertiary centre of Northern India. All COVID-19 positive pregnant women with gestational age ≥20 weeks, with placental histopathological reporting, were included in this study. A total of 173 COVID-19 pregnant women were included in the study.

RESULTS:

Placental abnormalities were noticed in 49·16% of total 179 placentae examined. Maternal vascular malperfusion (27·93%) was the most observed placental pathology followed by villous fibrin deposits (22·90%), fetal vasculopathy (16·75%), and acute inflammation (6·70%). Stillbirths were 22 and NICU admissions were seen in 50 neonates. Abnormal placental abnormalities led to higher stillbirths (p value 0·011) and lower Apgar scores at 1 and 5 min (p-value 0·028; p-value 0·002, respectively). Intervillous fibrin deposits had higher risk associated with lower Apgar score at 1 and 5 min [RR 2·05 (95% CI 1·21-3·48, p-value 0·010) and RR 5·52 (95% CI 2·58-11·81, p-value <0·001), respectively]. RP clot/hemorrhage was also associated with lower Apgar score at 1 and 5 min [RR 2·61 (95% CI 1·52-4·49, p-value 0·002) and RR 3.54 (95% CI 1·66-7·55, p-value 0·001), respectively].

DISCUSSION:

Placental abnormalities in COVID-19 infection were associated with significant higher incidence of unexplained stillbirths, and lower Apgar scores. Although, this is the largest descriptive-analytical study done so far, comparative studies are required to draw a clear conclusion regarding the impact of COVID-19 infection on human placenta and its effect on pregnancy outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Placenta Diseases / Pregnancy Complications, Infectious / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Female / Humans / Infant / Infant, Newborn / Pregnancy Language: English Journal: Placenta Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Placenta Diseases / Pregnancy Complications, Infectious / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Female / Humans / Infant / Infant, Newborn / Pregnancy Language: English Journal: Placenta Year: 2022 Document Type: Article