Suspension of Oncology Randomized Clinical Trials during the COVID-19 Pandemic: A Cross-Sectional Evaluation of COVID-Related Suspensions.
Cancer Invest
; 40(9): 743-749, 2022 Oct.
Article
in English
| MEDLINE | ID: covidwho-1937551
ABSTRACT
We conducted a cross-sectional analysis of ClinicalTrials.gov-registered oncology randomized controlled trials between September 2019 and December 2021 to identify predictors of trial suspensions. The dataset included 1,183 oncology trials, of which 384 (32.5%) were suspended. COVID-19 accounted for 47 (12.2%) suspensions. Trials that were single center- or US-based had higher odds of COVID-19 (ORs 3.85 and 2.48, 95% CIs 1.60-11.50 and 1.28-4.93, respectively) or any-reason suspensions (ORs 2.33 and 2.04, 95% CIs 1.46-3.45 and 1.40-2.76, respectively). Phase two (OR 1.27), three (OR 6.45) and four trials (OR 11.5) had increased odds of COVID-19 suspensions, compared to phase one trials.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Neoplasms
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
Cancer Invest
Year:
2022
Document Type:
Article
Affiliation country:
07357907.2022.2104305
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