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Suspension of Oncology Randomized Clinical Trials during the COVID-19 Pandemic: A Cross-Sectional Evaluation of COVID-Related Suspensions.
Sayyid, Rashid K; Hiffa, Anthony; Woodruff, Phillip; Oberle, Michael D; Lambert, Joshua H; Terris, Martha K; Wallis, Christopher J D; Klaassen, Zachary.
  • Sayyid RK; Section of Urology, Department of Surgery, Augusta University, Augusta, GA, USA.
  • Hiffa A; Section of Urology, Department of Surgery, Augusta University, Augusta, GA, USA.
  • Woodruff P; Section of Urology, Department of Surgery, Augusta University, Augusta, GA, USA.
  • Oberle MD; Section of Urology, Department of Surgery, Augusta University, Augusta, GA, USA.
  • Lambert JH; Section of Urology, Department of Surgery, Augusta University, Augusta, GA, USA.
  • Terris MK; Section of Urology, Department of Surgery, Augusta University, Augusta, GA, USA.
  • Wallis CJD; Georgia Cancer Center, Augusta University, Augusta, GA, USA.
  • Klaassen Z; Department of Surgery, Division of Urology, University of Toronto, Toronto, Canada.
Cancer Invest ; 40(9): 743-749, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-1937551
ABSTRACT
We conducted a cross-sectional analysis of ClinicalTrials.gov-registered oncology randomized controlled trials between September 2019 and December 2021 to identify predictors of trial suspensions. The dataset included 1,183 oncology trials, of which 384 (32.5%) were suspended. COVID-19 accounted for 47 (12.2%) suspensions. Trials that were single center- or US-based had higher odds of COVID-19 (ORs 3.85 and 2.48, 95% CIs 1.60-11.50 and 1.28-4.93, respectively) or any-reason suspensions (ORs 2.33 and 2.04, 95% CIs 1.46-3.45 and 1.40-2.76, respectively). Phase two (OR 1.27), three (OR 6.45) and four trials (OR 11.5) had increased odds of COVID-19 suspensions, compared to phase one trials.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Cancer Invest Year: 2022 Document Type: Article Affiliation country: 07357907.2022.2104305

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Cancer Invest Year: 2022 Document Type: Article Affiliation country: 07357907.2022.2104305