CLINICAL AND MORPHOLOGICAL FEATURES OF KIDNEY DAMAGE IN PATIENTS WITH ARTERIAL HYPERTENSION DIED OF SARSCOV- 2 INFECTION
Journal of Hypertension
; 40:e178, 2022.
Article
in English
| EMBASE | ID: covidwho-1937735
ABSTRACT
Objective:
To assess clinical and pathomorphological features of kidney damage in patients with arterial hypertension (AH) who died of the new coronavirus infection COVID-19. Design andmethod:
A complex analysis of 268 kidney autopsies was carried out, including the study of macro- and microscopic changes reflected in the protocols of pathological and anatomical autopsies and identified during the histological examination. In 224 patients (83.6%) with AH, the diagnosis was confirmed by isolating the SARS-CoV-2 RNA using the polymerase chain reaction;in 44 (16.4%) - through computed tomography of the lungs. The causes of deaths were the following in 31 patients (11.6%) acute myocardial infarction;in 40 (14.9%) cerebrovascular accident;in 11 (4.1%) pulmonary embolism;222 patients (83%) had acute respiratory distress syndrome. The analysis included 130 men aged 36 to 92 (72.6 years old on average) and 138 women aged 40 to 106 (77.1 years old on average).Results:
In the kidneys we detected ischemic changes caused by disturbances in the microvasculature. These are stases, sludges, erythrocyte and fibrin thrombi predominantly in the medulla. In the glomeruli diapedesis hemorrhages, mesangial cells proliferation, basement membrane thickening and fibrinoid necrosis of the capillary wall were observed. In the epithelium of the convoluted tubules, a granular, hyaline-drop dystrophy and a necrosis as the extreme degree of the damage were noted. In the kidneys, a pronounced lymphoid and leukocyte infiltration was detected. These changes were accompanied by inflammation and renal failure symptoms. In particular, the level of C-reactive protein was 140.6 ± 7.42 mg/l;blood ferritin 1258.0 ± 110.1 mcg/l;blood leukocytes 15.0 ± 0.67 10
C reactive protein; endogenous compound; ferritin; fibrin; fibrinogen; hyalin; procalcitonin; acute heart infarction; adult; adult respiratory distress syndrome; aged; autopsy; basement membrane; bleeding; blood clotting disorder; capillary wall; cause of death; cell proliferation; cerebrovascular accident; computer assisted tomography; conference abstract; controlled study; coronavirus disease 2019; creatinine blood level; diagnosis; diapedesis; dystrophy; epithelium; erythrocyte; female; ferritin blood level; fibrinoid necrosis; gene amplification; gene expression; histology; human; human cell; human tissue; hypertension; inflammation; kidney failure; kidney injury; kidney tubule; leukocyte; lung embolism; lymphocyte; major clinical study; male; mesangium cell; microvasculature; necrosis; nonhuman; polymerase chain reaction; protein expression; Severe acute respiratory syndrome coronavirus 2; sludge; thrombocyte; thrombus
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
Journal of Hypertension
Year:
2022
Document Type:
Article
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