Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrence.
Infect Agent Cancer
; 17(1): 38, 2022 Jul 18.
Article
in English
| MEDLINE | ID: covidwho-1938335
ABSTRACT
COVID-19 infection is a serious threat to patients with primary diseases, especially multiple cancers. Studies suggest that cancer patients are one of the most susceptible populations to experience severe COVID-19 and death. In addition, a number of studies suggest various mechanisms for SARS-CoV-2 in cancer progression. In this study, we discussed the role of SARS-CoV-2 in the induction of autophagy and we hypothesized that autophagy induced by COVID-19 not only can contribute to viral replication but also potentially can lead to cancer progression, chemo-resistance, and tumor recurrence in multiple cancer patients. Therefore, targeting autophagy-related signaling pathways and cellular and molecular processes could be a potentially promising therapeutic approach for cancer patients with COVID-19. Hence, this study can shed light on a new window on the management of such patients. However, more investigations in the future are required to understand other pathological effects of COVID-19 infection on cancer patients to provide new therapeutic strategies to combat these complications in these patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Infect Agent Cancer
Year:
2022
Document Type:
Article
Affiliation country:
S13027-022-00450-2
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