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COVID-19 in a Hairy Cell Leukemia Patient: A Rare Case Report.
Sano, Hirohito; Murakami, Koji; Yokoyama, Hisayuki; Suzuki, Chie; Iwasaki, Yudai; Kodama, Eiichi; Sugiura, Hisatoshi.
  • Sano H; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine.
  • Murakami K; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine.
  • Yokoyama H; Department of Hematology, Tohoku University Graduate School of Medicine.
  • Suzuki C; Laboratory Diagnostics, Tohoku University Hospital.
  • Iwasaki Y; Department of Anesthesiology and Perioperative Medicine, Tohoku University Graduate School of Medicine.
  • Kodama E; Department of Infectious Diseases, International Research Institute of Disaster Science, Graduate School of Medicine, Tohoku Medical Megabank Organization, Tohoku University.
  • Sugiura H; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine.
Tohoku J Exp Med ; 258(1): 63-68, 2022 Aug 10.
Article in English | MEDLINE | ID: covidwho-1938489
ABSTRACT
The detailed clinical course of coronavirus disease 2019 (COVID-19) in patients with hairy cell leukemia (HCL) is rarely reported. We report the first case of HCL diagnosed with prolonged pancytopenia after COVID-19 infection in Japan. We describe the case of a 56-year-old man who was diagnosed with COVID-19. Computed tomography revealed ground-glass opacities in the bilateral lung lobes as well as splenomegaly. Remdesivir and dexamethasone were administered for the treatment of COVID-19. Since the pancytopenia persisted, bone marrow examination was performed, and he was diagnosed with HCL. Although pancytopenia can occur with COVID-19 alone, clinicians should be alerted regarding the presence of hematologic malignancies in patients in whom pancytopenia persists after COVID-19 treatment or in those with splenomegaly. Further, the condition of all previously reported patients with COVID-19 associated with HCL was severe enough to require mechanical ventilation. This is the first case in which the disease was not severe. The interleukin-6 (IL-6) level was lower in this case than in previous cases, suggesting that racial differences in IL-6 production may have contributed to COVID-19 severity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancytopenia / Leukemia, Hairy Cell / Coronavirus / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Tohoku J Exp Med Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancytopenia / Leukemia, Hairy Cell / Coronavirus / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Tohoku J Exp Med Year: 2022 Document Type: Article