Prospective cohort study of referred Malawian children and their survival by hypoxaemia and hypoglycaemia status.
Bull World Health Organ
; 100(5): 302-314B, 2022 May 01.
Article
in English
| MEDLINE | ID: covidwho-1938580
ABSTRACT
Objective:
To investigate survival in children referred from primary care in Malawi, with a focus on hypoglycaemia and hypoxaemia progression.Methods:
The study involved a prospective cohort of children aged 12 years or under referred from primary health-care facilities in Mchinji district, Malawi in 2019 and 2020. Peripheral blood oxygen saturation (SpO2) and blood glucose were measured at recruitment and on arrival at a subsequent health-care facility (i.e. four hospitals and 14 primary health-care facilities). Children were followed up 2 weeks after discharge or their last clinical visit. The primary study outcome was the case fatality ratio at 2 weeks. Associations between SpO2 and blood glucose levels and death were evaluated using Cox proportional hazards models and the treatment effect of hospitalization was assessed using propensity score matching.Findings:
Of 826 children recruited, 784 (94.9%) completed follow-up. At presentation, hypoxaemia was moderate (SpO2 90-93%) in 13.1% (108/826) and severe (SpO2 < 90%) in 8.6% (71/826) and hypoglycaemia was moderate (blood glucose 2.5-4.0 mmol/L) in 9.0% (74/826) and severe (blood glucose < 2.5 mmol/L) in 2.3% (19/826). The case fatality ratio was 3.7% (29/784) overall but 26.3% (5/19) in severely hypoglycaemic children and 12.7% (9/71) in severely hypoxaemic children. Neither moderate hypoglycaemia nor moderate hypoxaemia was associated with mortality.Conclusion:
Presumptive pre-referral glucose treatment and better management of hypoglycaemia could reduce the high case fatality ratio observed in children with severe hypoglycaemia. The morbidity and mortality burden of severe hypoxaemia was high; ways of improving hypoxaemia identification and management are needed.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Blood Glucose
/
Hypoglycemia
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Bull World Health Organ
Year:
2022
Document Type:
Article
Affiliation country:
BLT.21.287265
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