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Noninvasive Respiratory Assist Devices in the Management of COVID-19-related Hypoxic Respiratory Failure: Pune ISCCM COVID-19 ARDS Study Consortium (PICASo).
Jog, Sameer; Zirpe, Kapil; Dixit, Subhal; Godavarthy, Purushotham; Shahane, Manasi; Kadapatti, Kayanoosh; Shah, Jignesh; Borawake, Kapil; Khan, Zafer; Shukla, Urvi; Jahagirdar, Ashwini; Dhat, Venkatesh; D'costa, Pradeep; Shelgaonkar, Jayant; Deshmukh, Abhijit; Khatib, Khalid; Prayag, Shirish.
  • Jog S; Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India.
  • Zirpe K; Neuro Trauma Unit, Grant Medical Foundation, Ruby Hall Clinic, Pune, Maharashtra, India.
  • Dixit S; Sanjeevan Hospital, Pune, Maharashtra, India.
  • Godavarthy P; Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India.
  • Shahane M; Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India.
  • Kadapatti K; Jehangir Hospital, Pune, Maharashtra, India.
  • Shah J; Bharati Vidyapeeth (Deemed to be) University Medical Hospital, Pune, Maharashtra, India.
  • Borawake K; Vishwaraj Hospital, Pune, Maharashtra, India.
  • Khan Z; Noble Hospital, Pune, Maharashtra, India.
  • Shukla U; Symbiosis University Hospital and Research Centre, Symbiosis International University, Pune, Maharashtra, India.
  • Jahagirdar A; Sahyadri Super Speciality Hospital, Pune, Maharashtra, India.
  • Dhat V; Aditya Birla Memorial Hospital, Pune, Maharashtra, India.
  • D'costa P; Sahyadri Hospital Nagar Road, Pune, Maharashtra, India.
  • Shelgaonkar J; Jupiter Hospital, Pune, Maharashtra, India.
  • Deshmukh A; Ruby Hall Clinic, Pune, Maharashtra, India.
  • Khatib K; Smt Kashibai Navale Medical College, Pune, Maharashtra, India.
  • Prayag S; Department of Critical Care Medicine, Prayag Hospital, Pune, Maharashtra, India.
Indian J Crit Care Med ; 26(7): 791-797, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1939282
ABSTRACT

Objective:

To determine whether high-flow nasal oxygen (HFNO) or noninvasive ventilator (NIV) can avoid invasive mechanical ventilation (IMV) in COVID-19-related acute respiratory distress syndrome (ADRS), and the outcome predictors of these modalities.

Design:

Multicenter retrospective study conducted in 12 ICUs in Pune, India. Patients Patients with COVID-19 pneumonia who had PaO2/FiO2 ratio <150 and were treated with HFNO and/or NIV. Intervention HFNO and/or NIV. Measurements The primary outcome was to assess the need of IMV. Secondary outcomes were death at Day 28 and mortality rates in different treatment groups. Main

results:

Among 1,201 patients who met the inclusion criteria, 35.9% (431/1,201) were treated successfully with HFNO and/or NIV and did not require IMV. About 59.5% (714/1,201) patients needed IMV for the failure of HFNO and/or NIV. About 48.3, 61.6, and 63.6% of patients who were treated with HFNO, NIV, or both, respectively, needed IMV. The need of IMV was significantly lower in the HFNO group (p <0.001). The 28-day mortality was 44.9, 59.9, and 59.6% in the patients treated with HFNO, NIV, or both, respectively (p <0.001). On multivariate regression analysis, presence of any comorbidity, SpO2 <90%, and presence of nonrespiratory organ dysfunction were independent and significant determinants of mortality (p <0.05).

Conclusions:

During COVID-19 pandemic surge, HFNO and/or NIV could successfully avoid IMV in 35.5% individuals with PO2/FiO2 ratio <150. Those who needed IMV due to failure of HFNO or NIV had high (87.5%) mortality. How to cite this article Jog S, Zirpe K, Dixit S, Godavarthy P, Shahane M, Kadapatti K, et al. Noninvasive Respiratory Assist Devices in the Management of COVID-19-related Hypoxic Respiratory Failure Pune ISCCM COVID-19 ARDS Study Consortium (PICASo). Indian J Crit Care Med 2022;26(7)791-797.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Variants Language: English Journal: Indian J Crit Care Med Year: 2022 Document Type: Article Affiliation country: Jp-journals-10071-24241

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Variants Language: English Journal: Indian J Crit Care Med Year: 2022 Document Type: Article Affiliation country: Jp-journals-10071-24241