Inactivated and mRNA COVID-19 Vaccines Affect F-18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Oncology Patients
HONG KONG JOURNAL OF RADIOLOGY
; 25(2):94-102, 2022.
Article
in English
| Web of Science | ID: covidwho-1939425
ABSTRACT
Introduction:
We aimed to analyse the effect of coronavirus disease 2019 (COVID-19) vaccination on F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging findings in cancer patients.Methods:
A total of 165 oncology patients who underwent FDG PET/CT between 1 May 2021 and 30 September 2021 after their first or second COVID-19 vaccination with were included in this retrospective study. The occurrence and pattern of FDG uptake at the injection site (usually deltoid), ipsilateral axillary and other regional lymph nodes, were measured.Results:
Overall, the incidence of FDG-avid ipsilateral regional nodal uptake was 26.7% (44/165), with a median maximal standardised uptake value of 3.2 (range, 1.7-13.8). Vaccine-associated hypermetabolic lymphadenopathy (VAHL) was found in 11.4% (5/44) of the subjects beyond 6 weeks after vaccination. VAHL was more common in patients receiving BioNTech-Fosun mRNA vaccine (compared with patients receiving the Sinovac CoronaVac inactivated vaccine), and in women (p < 0.05).Conclusion:
VAHL is common and can be observed beyond 6 weeks after vaccination. It was seen more frequently in women and in patients receiving the mRNA-based vaccine. Proper vaccination history documentation, locating the vaccination site contralateral to the primary cancer, and appropriate scheduling of FDG PET/CT are advisable for correct image interpretation.
Full text:
Available
Collection:
Databases of international organizations
Database:
Web of Science
Topics:
Vaccines
Language:
English
Journal:
HONG KONG JOURNAL OF RADIOLOGY
Year:
2022
Document Type:
Article
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