Elevated Serum Levels of MCP-1 and IP-10 Chemokines in Patients with COVID-19 Infection

ABSTRACT

Background: There are little researches taken discussed the effect of IP-10 and MCP-1 in the coronavirus infection. Therefore, our study mainly aims to estimate whether IP-10 and MCP-1 is associated to disease severity in a samples of Iraqi patients with COVID-19. Methods: The Cross-sectional study included 90 patients infected with covid-19 virus divided in to (45) with severe infection and (45) with mild infection,51 males and 39 females. Serum levels of MCP-1 and IP-10 was measured by sandwich ELISA test. Results: MCP-1 chemokine in severe COVID-19 patients was significantly higher (P=0.000) than in mild patients. Also, IP-10 chemokine showing a higher significant association (P =0.025) with severe patients group. There is a highly significant difference of Oxygen saturation in the distribution of mild and severe patients (P= 0.000). The Computed Tomography, Ferritin and D.dimer showing a higher significant association with severe patients (P=0.000) compared with mild patients. Conclusion: According to the current study the serum levels of Interferon Gamma Induced Protein 10 (IP-10) and Monocyte Chemotactic Protein 1 (MCP-1) showing a significant association with the severe COVID-19 infections.