Adults with Congenital Heart Disease during the COVID-19 Era: One-Year Tertiary Center Experience
Congenital Heart Disease
; 17(4):399-419, 2022.
Article
in English
| EMBASE | ID: covidwho-1939710
ABSTRACT
Background:
Adult patients with congenital heart disease (ACHD) might be at high risk of Coronavirus disease-2019 (COVID-19). This study aimed to report on a one-year tertiary center experience regards COVID-19 infection in ACHD patients.Methods:
This is a one-year (March-2020 to March-2021) tertiary-center retrospective study that enrolled all ACHD patients;COVID-19 positive patients’ medical records, and management were reported.Results:
We recorded 542 patients, 205 (37.8%) COVID-19-positive, and 337 (62.2%) COVID-19-negative patients. Palliated single ventricle and Eisenmenger syndrome patients were more vulnerable to COVID-19 infection (P < 0.05*). Cardiovascular COVID-19 complications were arrhythmias in 47 (22.9%) patients, heart failure in 39 (19.0%) patients, cyanosis in 12 (5.9%) patients, stroke/TIA in 5 (2.4%) patients, hypertension and infective endo-carditis in 2 (1.0%) patients for each, pulmonary hypertension and pulmonary embolism in 1 (0.5%) patient for each. 11 (5.4%) patients were managed with home isolation, 147 (71.7%) patients required antibiotics, 32 (15.6%) patients required intensive care unit (ICU), 8 (3.9%) patients required inotropes, 7 (3.4%) patients required mechanical ventilation, and 2 (1.0%) patients required extracorporeal membrane oxygenation (ECMO). Thromboprophylaxis was given to all 46 (22.4%) hospitalized patients. American College of Cardiology/American Heart Association classification revealed that complex lesions, and FC-C/D categories were more likely to develop severe/critical symptoms, that required mechanical ventilation and ECMO (P < 0.05*). Mortality was reported in 3 (0.6%) patients with no difference between groups (P = 0.872). 193 (35.6%) patients were vaccinated.Conclusions:
COVID-19 infection in ACHD patients require individualized risk stratification and management. Eisenmenger syndrome, single ventricle palliation, complex lesions, and FC-C/D patients were more vulnerable to severe/critical symptoms that required ICU admission, mechanical ventilation, and ECMO. The vaccine was mostly tolerable.
adult; article; artificial ventilation; cardiology; cerebrovascular accident; complication; congenital heart disease; coronavirus disease 2019; cyanosis; Eisenmenger complex; endocarditis; extracorporeal oxygenation; female; heart arrhythmia; heart failure; heart single ventricle; home quarantine; hospital patient; human; hypertension; intensive care unit; lung embolism; major clinical study; male; medical record; medical society; mortality; palliative therapy; pandemic; pulmonary hypertension; retrospective study; risk assessment; thrombosis prevention; antibiotic agent; inotropic agent; vaccine
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Congenital Heart Disease
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS