A systematic review and meta-analysis on the association between lymphocyte subsets and the severity of COVID-19
IMMUNOPATHOLOGIA PERSA
; 8(2), 2022.
Article
in English
| Web of Science | ID: covidwho-1939728
ABSTRACT
Introduction:
Prominent prognostic parameters that reflect the severity of coronavirus disease 2019 (COVID-19) to adopt an appropriate therapeutic approach are not fully identified. This systematic review and meta-analysis aimed to explore the association between lymphocyte variation and disease severity in COVID-19 individuals.Methods:
We searched Web of Science, Scopus, PubMed, EMBASE and WHO website to retrieve studies investigating lymphocyte subset counts in non-severe and severe cases of COVID-19. The pooled standardized mean difference (SMD) between two groups and the pooled average count of each lymphocyte subset were assessed by employing a random-effect model.Results:
Thirty-nine investigations on 5087 participants, including 3578 non-severe patients and 1509 severe patients, were included. The pooled analysis showed that non-severe patients had higher total T lymphocytes (SMD = 1.01;95% CI 0.82, 1.20;I2 = 75.7%), T helper cells (SMD = 1.07;95% CI 0.85, 1.28;I2 = 85.4%), T cytotoxic cells (SMD = 1.07;95% CI 0.82, 1.32;I2 = 87.1%), B cells (SMD = 0.72;95% CI 0.45, 0.98;I2 = 79.7%), and natural killer cells (SMD = 0.65;95% CI 0.47, 0.84;I2 = 63.1%) than severe patients and the average count of the corresponding lymphocyte signatures in non-severe patients/severe patients were 878.88/448.40, 493.12/268.96, 311.91/158.91, 177.09/110.37, and 155.02/103.09 cells/mu L, respectively.Conclusion:
Lymphopenia may be a dilemma in COVID-19 management because over-activation of lymphocytes may lead to cytokine storm or acute respiratory distress syndrome (ARDS). In contrast, lymphopenia may increase SARS-CoV-2 amplification and COVID-19 severity. Therefore, novel therapies targeting lymphocyte proliferation or contraction may counterbalance lymphocyte counts in these patients.
Full text:
Available
Collection:
Databases of international organizations
Database:
Web of Science
Type of study:
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Language:
English
Journal:
IMMUNOPATHOLOGIA PERSA
Year:
2022
Document Type:
Article
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