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Evaluating the Effects of Curcumin on the Cytokine Storm in COVID-19 Using a Chip-Based Multiplex Analysis.
Zahedipour, Fatemeh; Guest, Paul C; Majeed, Muhammed; Moallem, Seyed Adel; Kesharwani, Prashant; Jamialahmadi, Tannaz; Sahebkar, Amirhossein.
  • Zahedipour F; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Guest PC; Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Majeed M; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
  • Moallem SA; Sabinsa Corporation, East Windsor, NJ, USA.
  • Kesharwani P; Department of Pharmacology and Toxicology, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq.
  • Jamialahmadi T; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Sahebkar A; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Methods Mol Biol ; 2511: 285-295, 2022.
Article in English | MEDLINE | ID: covidwho-1941383
ABSTRACT
SARS-CoV-2 can stimulate the expression of various inflammatory cytokines and induce the cytokine storm in COVID-19 patients leading to multiple organ failure and death. Curcumin as a polyphenolic compound has been shown to have anti-inflammatory properties and inhibit the release of numerous pro-inflammatory cytokines. We present multiplex analysis using the Evidence Investigator biochip system to determine the effect of curcumin on serum level of cytokines which are typically elevated in cytokine storm events, including tumor necrosis factor (TNF-α), interleukin 6 (IL-6), and IL-10.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Curcumin / Cytokine Release Syndrome / COVID-19 Drug Treatment Type of study: Experimental Studies Limits: Humans Language: English Journal: Methods Mol Biol Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: 978-1-0716-2395-4_21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Curcumin / Cytokine Release Syndrome / COVID-19 Drug Treatment Type of study: Experimental Studies Limits: Humans Language: English Journal: Methods Mol Biol Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: 978-1-0716-2395-4_21