Your browser doesn't support javascript.
Impact of bariatric surgery on the effectiveness of serological response after COVID-19 vaccination.
Hany, Mohamed; Torensma, Bart; Abouelnasr, Anwar Ashraf; Zidan, Ahmed; Ibrahim, Mohamed; Agayby, Ann Samy Shafiq; Hesham, Mohamed; Elsheredy, Amel; Abu-Sheasha, Ghada Ahmed.
  • Hany M; Department of Surgery, Medical Research Institute, Alexandria University, Alexandria, Egypt. mohamed.ashour@alexu.edu.eg.
  • Torensma B; Clinical Epidemiologist, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
  • Abouelnasr AA; Department of Surgery, Medical Research Institute, Alexandria University, Alexandria, Egypt.
  • Zidan A; Department of Surgery, Medical Research Institute, Alexandria University, Alexandria, Egypt.
  • Ibrahim M; Department of Surgery, Medical Research Institute, Alexandria University, Alexandria, Egypt.
  • Agayby ASS; Department of Surgery, Medical Research Institute, Alexandria University, Alexandria, Egypt.
  • Hesham M; Department of Pharmacology, Alexandria University, Alexandria, Egypt.
  • Elsheredy A; Department of Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egypt.
  • Abu-Sheasha GA; Department of Bio-Medical Informatics and Medical Statistics, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Langenbecks Arch Surg ; 407(6): 2337-2346, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1941630
ABSTRACT

PURPOSE:

The primary objective of the current study is to determine whether bariatric surgery reversed the negative impact of obesity on the serological response after the COVID-19 vaccination. This objective is achieved in two

steps:

(a) quantifying the negative impact of obesity on the serological response after COVID-19 vaccination if it is present, and (b) testing whether bariatric surgery reversed this impact. The secondary objective was to monitor the occurrence of adverse events.

METHODS:

This is a prospective cohort study between May 2021 and August 2021 on the strength of serological response after COVID-19 vaccination. Patients were classified into three groups. Group A (controls with normal or overweight), Group B (bariatric patients pre-operative), and Group C (bariatric patients post-operative). Quantitative antibodies against SARS­CoV­2 RBD with a strong neutralizing capacity were quantified from sera after at least 2 weeks post-vaccination.

RESULTS:

Of the 276 participants, Group A had n = 73, Group B had n = 126, and Group C had n = 77 patients. Overall, a strongly positive vaccine serological response was observed among 86% in group A, 63% in Group B, and 88% in Group C. Group C showed 5.33 times [95% CI 2.15 to 13.18] higher immune response than group B. Mild to moderate adverse events occurred in 30.1% [95% CI 24.7 to 35.9] of the study samples. Adverse events with the whole virus, mRNA, and vector vaccines occurred in 25%, 28%, and 37%, respectively.

CONCLUSION:

Vaccinating and bariatric surgery are safe and effective treatments in the serological response in patients who suffer from obesity.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Bariatric Surgery / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Langenbecks Arch Surg Year: 2022 Document Type: Article Affiliation country: S00423-022-02516-6

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Bariatric Surgery / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Langenbecks Arch Surg Year: 2022 Document Type: Article Affiliation country: S00423-022-02516-6