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Intestinal microbiota composition of children with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome (MIS-C).
Suskun, Cansu; Kilic, Omer; Yilmaz Ciftdogan, Dilek; Guven, Sirin; Karbuz, Adem; Ozkaya Parlakay, Aslinur; Kara, Yalcin; Kacmaz, Ebru; Sahin, Aslihan; Boga, Aysun; Kizmaz Isancli, Didem; Gulhan, Belgin; Kanik-Yuksek, Saliha; Kiral, Eylem; Bozan, Gurkan; Arslanoglu, Mehmet Ozgür; Kizil, Mahmut Can; Dinleyici, Meltem; Us, Tercan; Varis, Ahmet; Kaya, Mucahit; Vandenplas, Yvan; Dinleyici, Ener Cagri.
  • Suskun C; Department of Pediatrics, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, TR-26040, Turkey.
  • Kilic O; Department of Pediatric Infectious Disease, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Yilmaz Ciftdogan D; Department of Pediatric Infectious Disease, Izmir Katip Celebi University Faculty of Medicine, Izmir, Turkey.
  • Guven S; Department of Pediatrics, Prof. Dr Ilhan Varank Training and Research Hospital, Istanbul, Turkey.
  • Karbuz A; Department of Pediatric Infectious Disease, Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.
  • Ozkaya Parlakay A; Yildirim Beyazit University Faculty of Medicine Department of Pediatric Infectious Disease, Ankara City Hospital Department of Pediatric Infectious Disease, Ankara, Turkey.
  • Kara Y; Department of Pediatric Infectious Disease, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Kacmaz E; Pediatric Intensive Care Unit, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Sahin A; Department of Pediatric Infectious Disease, Izmir Katip Celebi University Faculty of Medicine, Izmir, Turkey.
  • Boga A; Department of Pediatrics, Prof. Dr Ilhan Varank Training and Research Hospital, Istanbul, Turkey.
  • Kizmaz Isancli D; Department of Pediatric Infectious Disease, Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.
  • Gulhan B; Department of Pediatric Infectious Disease, Ankara City Hospital, Ankara, Turkey.
  • Kanik-Yuksek S; Department of Pediatric Infectious Disease, Ankara City Hospital, Ankara, Turkey.
  • Kiral E; Pediatric Intensive Care Unit, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Bozan G; Pediatric Intensive Care Unit, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Arslanoglu MO; Pediatric Intensive Care Unit, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Kizil MC; Department of Pediatric Infectious Disease, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Dinleyici M; Department of Social Pediatrics, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Us T; Department of Microbiology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Varis A; Diagen Biotechnology, Ankara, Turkey.
  • Kaya M; Diagen Biotechnology, Ankara, Turkey.
  • Vandenplas Y; KidZ Health Castle, UZ Brussels, Vrije Universiteit Brussel, Brussels, Belgium.
  • Dinleyici EC; Department of Pediatrics, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, TR-26040, Turkey. timboothtr@yahoo.com.
Eur J Pediatr ; 181(8): 3175-3191, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1941645
ABSTRACT
Microbiota composition may play a role in the development, prognosis, or post-infection of COVID-19. There are studies evaluating the microbiota composition at the time of diagnosis and during the course of COVID-19, especially in adults, while studies in children are limited and no study available in children with multisystem inflammatory syndrome in children (MIS-C). This study was planned to compare intestinal microbiota composition in children diagnosed with MIS-C and acute COVID-19 infection with healthy children. In this prospective multicenter study, 25 children diagnosed with MIS-C, 20 with COVID-19 infection, and 19 healthy children were included. Intestinal microbiota composition was evaluated by 16 s rRNA gene sequencing. We observed changes of diversity, richness, and composition of intestinal microbiota in MIS-C cases compared to COVID-19 cases and in the healthy controls. The Shannon index was higher in the MIS-C group than the healthy controls (p < 0.01). At phylum level, in the MIS-C group, a significantly higher relative abundance of Bacteroidetes and lower abundance of Firmicutes was found compared to the control group. Intestinal microbiota composition changed in MIS-C cases compared to COVID-19 and healthy controls, and Faecalibacterium prausnitzii decreased; Bacteroides uniformis, Bacteroides plebeius, Clostridium ramosum, Eubacterium dolichum, Eggerthella lenta, Bacillus thermoamylovorans, Prevotella tannerae, and Bacteroides coprophilus were dominant in children with MIS-C. At species level, we observed decreased Faecalibacterium prausnitzii, and increased Eubacterium dolichum, Eggerthella lenta, and Bacillus thermoamylovorans in children with MIS-C and increased Bifidobacterium adolescentis and Dorea formicigenerasus in the COVID-19 group. Our study is the first to evaluate the microbiota composition in MIS-C cases. There is a substantial change in the composition of the gut microbiota (1) reduction of F. prausnitzii in children with MIS-C and COVID-19; (2) an increase of Eggerthella lenta which is related with autoimmunity; and (3) the predominance of E. dolichum is associated with metabolic dysfunctions and obesity in children with MIS-C.

CONCLUSIONS:

 Alterations of the intestinal microbiota might be part of pathogenesis of predisposing factor for MIS-C. It would be beneficial to conduct more extensive studies on the cause-effect relationship of these changes in microbiota composition and their effects on long-term prognosis. WHAT IS KNOWN • Microbiota composition may play a role in the development, prognosis, or post-infection of COVID-19.  • However, the number of studies on children is limited, and no study on multisystem inflammatory syndrome in children is currently available (MIS-C). WHAT IS NEW • In individuals with MIS-C, the composition of the gut microbiota changed dramatically. • Decreased Faecalibacterium prausnitzii have been observed, increased Eggerthella lenta, which was previously linked to autoimmunity, and predominance of Eubacterium dolichum which was linked to metabolic dysfunction and obesity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pediatric Obesity / Gastrointestinal Microbiome / COVID-19 Type of study: Cohort study / Etiology study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Child / Humans Language: English Journal: Eur J Pediatr Year: 2022 Document Type: Article Affiliation country: S00431-022-04494-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pediatric Obesity / Gastrointestinal Microbiome / COVID-19 Type of study: Cohort study / Etiology study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Child / Humans Language: English Journal: Eur J Pediatr Year: 2022 Document Type: Article Affiliation country: S00431-022-04494-9