COVID-19 and Avoiding Ibuprofen. How Good Is the Evidence?
Am J Ther
; 27(4): e400-e402, 2020.
Article
in English
| MEDLINE | ID: covidwho-194451
ABSTRACT
Ibuprofen is an over-the-counter medication that is used widely for the treatment of pain and fever during COVID-19 pandemic. A concern was raised regarding the safety of ibuprofen use because of its role in increasing ACE2 levels within the Renin-Angiotensin-Aldosterone system. ACE2 is the coreceptor for the entry of SARS-CoV-2 into cells, and so, a potential increased risk of contracting COVID-19 disease and/or worsening of COVID-19 infection was feared with ibuprofen use. However, available data from limited studies show administration of recombinant ACE2 improves lung damage caused by respiratory viruses, suggesting ibuprofen use may be beneficial in COVID-19 disease. At this time, there is no supporting evidence to discourage the use of ibuprofen.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Anti-Inflammatory Agents, Non-Steroidal
/
Ibuprofen
/
Coronavirus Infections
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Animals
/
Humans
Language:
English
Journal:
Am J Ther
Journal subject:
Therapeutics
Year:
2020
Document Type:
Article
Affiliation country:
MJT.0000000000001196
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