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Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
Burnett, Cassandra E; Okholm, Trine Line Hauge; Tenvooren, Iliana; Marquez, Diana M; Tamaki, Stanley; Munoz Sandoval, Priscila; Willmore, Andrew; Hendrickson, Carolyn M; Kangelaris, Kirsten N; Langelier, Charles R; Krummel, Matthew F; Woodruff, Prescott G; Calfee, Carolyn S; Erle, David J; Ansel, K Mark; Spitzer, Matthew H.
  • Burnett CE; Department of Otolaryngology-Head and Neck Cancer, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Immunology & Immunology and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Com
  • Okholm TLH; Department of Otolaryngology-Head and Neck Cancer, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Immunology & Immunology and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Com
  • Tenvooren I; Department of Otolaryngology-Head and Neck Cancer, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Immunology & Immunology and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Com
  • Marquez DM; Department of Otolaryngology-Head and Neck Cancer, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Immunology & Immunology and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Com
  • Tamaki S; UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Munoz Sandoval P; Department of Immunology & Immunology and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Willmore A; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA.
  • Hendrickson CM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
  • Kangelaris KN; Division of Hospital Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Langelier CR; Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Krummel MF; UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94115, USA; ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Woodruff PG; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
  • Calfee CS; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA.
  • Erle DJ; UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA; ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center,
  • Ansel KM; Department of Immunology & Immunology and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Spitzer MH; Department of Otolaryngology-Head and Neck Cancer, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Immunology & Immunology and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Com
Immunity ; 55(7): 1284-1298.e3, 2022 07 12.
Article in English | MEDLINE | ID: covidwho-1945246
ABSTRACT
While studies have elucidated many pathophysiological elements of COVID-19, little is known about immunological changes during COVID-19 resolution. We analyzed immune cells and phosphorylated signaling states at single-cell resolution from longitudinal blood samples of patients hospitalized with COVID-19, pneumonia and/or sepsis, and healthy individuals by mass cytometry. COVID-19 patients showed distinct immune compositions and an early, coordinated, and elevated immune cell signaling profile associated with early hospital discharge. Intra-patient longitudinal analysis revealed changes in myeloid and T cell frequencies and a reduction in immune cell signaling across cell types that accompanied disease resolution and discharge. These changes, together with increases in regulatory T cells and reduced signaling in basophils, also accompanied recovery from respiratory failure and were associated with better outcomes at time of admission. Therefore, although patients have heterogeneous immunological baselines and highly variable disease courses, a core immunological trajectory exists that defines recovery from severe SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2022 Document Type: Article