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Impact of rhinovirus on hospitalization during the COVID-19 pandemic: A prospective cohort study.
Scotta, Marcelo Comerlato; Kern, Luciane Beatriz; Polese-Bonatto, Márcia; Azevedo, Thais Raupp; Varela, Fernanda Hammes; Zavaglia, Gabriela Oliveira; Fernandes, Ingrid Rodrigues; de David, Caroline Nespolo; Fazolo, Tiago; da Costa, Marcela Santos Corrêa; de Carvalho, Felipe Cotrim; Sartor, Ivaine Tais Sauthier; Zavascki, Alexandre Prehn; Stein, Renato T.
  • Scotta MC; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, Brazil; School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: marcelo.scotta@hmv.org.br.
  • Kern LB; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, Brazil. Electronic address: luciane.kern@hmv.org.br.
  • Polese-Bonatto M; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Azevedo TR; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Varela FH; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, Brazil; School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
  • Zavaglia GO; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Fernandes IR; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • de David CN; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Fazolo T; Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil.
  • da Costa MSC; General Coordination, Health Surveillance Secretariat, Brazilian Ministry of Health, Brasilia, Brazil.
  • de Carvalho FC; General Coordination, Health Surveillance Secretariat, Brazilian Ministry of Health, Brasilia, Brazil.
  • Sartor ITS; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Zavascki AP; Infectious Diseases Service, Hospital Moinhos de Vento, Porto Alegre, Brazil; Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Stein RT; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, Brazil; School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
J Clin Virol ; 156: 105197, 2022 11.
Article in English | MEDLINE | ID: covidwho-1945514
ABSTRACT

BACKGROUND:

Although the clinical course of the COVID-19 in adults has been extensively described, the impact of the co-detection of SARS-CoV-2 and rhinovirus on severity outcomes is not understood.

OBJECTIVES:

This study aimed to compare the risk of hospitalization of outpatients with COVID-19 with and without the co-detection of rhinovirus in southern Brazil. Secondarily, such risk was also compared between all individuals with COVID-19 and those with single rhinovirus infection. STUDY

DESIGN:

Outpatients (>18 years) with acute signs of cough, fever, or sore throat were prospectively enrolled at two emergency departments from May to September 2020. Sample collection was performed to detect SARS-CoV-2 and other 20 respiratory pathogens. Participants were followed for 28 days through telephone interviews.

RESULTS:

1,047 participants were screened and 1,044 were included. Of these, 4.9% were lost during follow-up, and 993/1,044 (95.1%) were included in severity-related analysis. Rhinovirus was the most prevalent pathogen (25.0%, 248/993), followed by SARS-CoV-2 (22.6%, 224/993), with coinfection of these two viruses occurring in 91/993 (9.2%) participants. The risk of COVID-19-related hospitalizations were not different between individuals with and without co-detection of rhinovirus (9.9% vs. 7.6%, respectively, P = 0.655). Conversely, subjects with COVID-19 had a higher hospitalization risk than single rhinovirus infection (8.3 vs 0.4%, respectively, P < 0.001).

CONCLUSIONS:

The co-detection of SARS-CoV-2 and rhinovirus did not change the risk of hospitalizations in adults. Furthermore, COVID-19 was more severe than single rhinovirus infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: J Clin Virol Journal subject: Virology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: J Clin Virol Journal subject: Virology Year: 2022 Document Type: Article