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The ratio of serum LL-37 levels to blood leucocyte count correlates with COVID-19 severity.
Keutmann, Matthias; Hermes, Gabriele; Meinberger, Denise; Roth, Annika; Stemler, Jannik; Cornely, Oliver A; Klatt, Andreas R; Streichert, Thomas.
  • Keutmann M; Faculty of Medicine and University Hospital Cologne, University of Cologne, Institute for Clinical Chemistry, 50937, Cologne, Germany.
  • Hermes G; Faculty of Medicine and University Hospital Cologne, University of Cologne, Institute for Clinical Chemistry, 50937, Cologne, Germany.
  • Meinberger D; Faculty of Medicine and University Hospital Cologne, University of Cologne, Institute for Clinical Chemistry, 50937, Cologne, Germany.
  • Roth A; Faculty of Medicine and University Hospital Cologne, University of Cologne, Institute for Clinical Chemistry, 50937, Cologne, Germany.
  • Stemler J; Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931, Cologne, Germany.
  • Cornely OA; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), University of Cologne, 50937, Cologne, Germany.
  • Klatt AR; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, 50931, Cologne, Germany.
  • Streichert T; Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931, Cologne, Germany.
Sci Rep ; 12(1): 9447, 2022 06 08.
Article in English | MEDLINE | ID: covidwho-1947477
ABSTRACT
Beneficial effects of vitamin D on COVID-19 progression have been discussed in several studies. Vitamin D stimulates the expression of the antimicrobial peptide LL-37, and evidence shows that LL-37 can antagonize SARS-CoV-2. Therefore, we investigated the association between LL-37 and vitamin D serum levels and the severity of COVID-19. To this end, 78 COVID-19 patients were divided into 5 groups according to disease severity. We determined serum levels of LL-37, vitamin D, and routine laboratory parameters. We demonstrated a correlation of CRP, IL-6, PCT, leukocyte count, and LDH with the severity of COVID-19. Our study did not demonstrate a direct relationship between serum levels of LL-37 and vitamin D and the severity of COVID-19. LL-37 is produced by granulocytes and released at the site of inflammation. Therefore, the analysis of LL-37 in broncho-alvelolar lavage rather than in patient serum seems critical. However, since LL-37 is produced by granulocytes, we determined serum LL-37 levels as a function of leukocyte count. The LL-37/leukocyte count ratio correlates highly significantly inversely proportional with COVID-19 severity. Our results indicate that the LL-37/leukocyte count ratio could be used to assess the risk of COVID-19 progression as early as hospital admission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-13260-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-13260-8