Your browser doesn't support javascript.
The phylodynamics of SARS-CoV-2 during 2020 in Finland.
Truong Nguyen, Phuoc; Kant, Ravi; Van den Broeck, Frederik; Suvanto, Maija T; Alburkat, Hussein; Virtanen, Jenni; Ahvenainen, Ella; Castren, Robert; Hong, Samuel L; Baele, Guy; Ahava, Maarit J; Jarva, Hanna; Jokiranta, Suvi Tuulia; Kallio-Kokko, Hannimari; Kekäläinen, Eliisa; Kirjavainen, Vesa; Kortela, Elisa; Kurkela, Satu; Lappalainen, Maija; Liimatainen, Hanna; Suchard, Marc A; Hannula, Sari; Ellonen, Pekka; Sironen, Tarja; Lemey, Philippe; Vapalahti, Olli; Smura, Teemu.
  • Truong Nguyen P; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Kant R; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Van den Broeck F; Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
  • Suvanto MT; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
  • Alburkat H; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Virtanen J; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Ahvenainen E; Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
  • Castren R; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Hong SL; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Baele G; Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
  • Ahava MJ; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Jarva H; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Jokiranta ST; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
  • Kallio-Kokko H; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
  • Kekäläinen E; HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Kirjavainen V; HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Kortela E; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
  • Kurkela S; Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
  • Lappalainen M; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
  • Liimatainen H; Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
  • Suchard MA; HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Hannula S; HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Ellonen P; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
  • Sironen T; HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Lemey P; Infectious Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Vapalahti O; HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Smura T; HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Commun Med (Lond) ; 2: 65, 2022.
Article in English | MEDLINE | ID: covidwho-1947557
ABSTRACT

Background:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of infections and fatalities globally since its emergence in late 2019. The virus was first detected in Finland in January 2020, after which it rapidly spread among the populace in spring. However, compared to other European nations, Finland has had a low incidence of SARS-CoV-2. To gain insight into the origins and turnover of SARS-CoV-2 lineages circulating in Finland in 2020, we investigated the phylogeographic and -dynamic history of the virus.

Methods:

The origins of SARS-CoV-2 introductions were inferred via Travel-aware Bayesian time-measured phylogeographic analyses. Sequences for the analyses included virus genomes belonging to the B.1 lineage and with the D614G mutation from countries of likely origin, which were determined utilizing Google mobility data. We collected all available sequences from spring and fall peaks to study lineage dynamics.

Results:

We observed rapid turnover among Finnish lineages during this period. Clade 20C became the most prevalent among sequenced cases and was replaced by other strains in fall 2020. Bayesian phylogeographic reconstructions suggested 42 independent introductions into Finland during spring 2020, mainly from Italy, Austria, and Spain.

Conclusions:

A single introduction from Spain might have seeded one-third of cases in Finland during spring in 2020. The investigations of the original introductions of SARS-CoV-2 to Finland during the early stages of the pandemic and of the subsequent lineage dynamics could be utilized to assess the role of transboundary movements and the effects of early intervention and public health measures.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Commun Med (Lond) Year: 2022 Document Type: Article Affiliation country: S43856-022-00130-7

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Commun Med (Lond) Year: 2022 Document Type: Article Affiliation country: S43856-022-00130-7