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Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age.
Tan, Sharon H X; Cook, Alex R; Heng, Derrick; Ong, Benjamin; Lye, David C; Tan, Kelvin B.
  • Tan SHX; From the Saw Swee Hock School of Public Health (S.H.X.T., A.R.C., D.H., K.B.T.) and the Yong Loo Lin School of Medicine (D.C.L.), National University of Singapore, the Ministry of Health (D.H., B.O., K.B.T.), the National Centre for Infectious Diseases (D.C.L.), Tan Tock Seng Hospital (D.C.L.), the
  • Cook AR; From the Saw Swee Hock School of Public Health (S.H.X.T., A.R.C., D.H., K.B.T.) and the Yong Loo Lin School of Medicine (D.C.L.), National University of Singapore, the Ministry of Health (D.H., B.O., K.B.T.), the National Centre for Infectious Diseases (D.C.L.), Tan Tock Seng Hospital (D.C.L.), the
  • Heng D; From the Saw Swee Hock School of Public Health (S.H.X.T., A.R.C., D.H., K.B.T.) and the Yong Loo Lin School of Medicine (D.C.L.), National University of Singapore, the Ministry of Health (D.H., B.O., K.B.T.), the National Centre for Infectious Diseases (D.C.L.), Tan Tock Seng Hospital (D.C.L.), the
  • Ong B; From the Saw Swee Hock School of Public Health (S.H.X.T., A.R.C., D.H., K.B.T.) and the Yong Loo Lin School of Medicine (D.C.L.), National University of Singapore, the Ministry of Health (D.H., B.O., K.B.T.), the National Centre for Infectious Diseases (D.C.L.), Tan Tock Seng Hospital (D.C.L.), the
  • Lye DC; From the Saw Swee Hock School of Public Health (S.H.X.T., A.R.C., D.H., K.B.T.) and the Yong Loo Lin School of Medicine (D.C.L.), National University of Singapore, the Ministry of Health (D.H., B.O., K.B.T.), the National Centre for Infectious Diseases (D.C.L.), Tan Tock Seng Hospital (D.C.L.), the
  • Tan KB; From the Saw Swee Hock School of Public Health (S.H.X.T., A.R.C., D.H., K.B.T.) and the Yong Loo Lin School of Medicine (D.C.L.), National University of Singapore, the Ministry of Health (D.H., B.O., K.B.T.), the National Centre for Infectious Diseases (D.C.L.), Tan Tock Seng Hospital (D.C.L.), the
N Engl J Med ; 387(6): 525-532, 2022 08 11.
Article in English | MEDLINE | ID: covidwho-1947717
ABSTRACT

BACKGROUND:

Since it was first identified in early November 2021, the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread quickly and replaced the B.1.617.2 (delta) variant as the dominant variant in many countries. Data on the real-world effectiveness of vaccines against the omicron variant in children are lacking.

METHODS:

In a study conducted from January 21, 2022, through April 8, 2022, when the omicron variant was spreading rapidly, we analyzed data on children in Singapore who were 5 to 11 years of age. We assessed the incidences of all reported SARS-CoV-2 infections (confirmed on polymerase-chain-reaction [PCR] assay, rapid antigen testing, or both), SARS-CoV-2 infections confirmed on PCR assay, and coronavirus disease 2019 (Covid-19)-related hospitalizations among unvaccinated, partially vaccinated (≥1 day after the first dose of vaccine and up to 6 days after the second dose), and fully vaccinated children (≥7 days after the second dose). Poisson regression was used to estimate vaccine effectiveness from the incidence rate ratio of outcomes.

RESULTS:

A total of 255,936 children were included in the analysis. Among unvaccinated children, the crude incidence rates of all reported SARS-CoV-2 infections, PCR-confirmed SARS-CoV-2 infections, and Covid-19-related hospitalizations were 3303.5, 473.8, and 30.0 per 1 million person-days, respectively. Among partially vaccinated children, vaccine effectiveness was 13.6% (95% confidence interval [CI], 11.7 to 15.5) against all SARS-CoV-2 infections, 24.3% (95% CI, 19.5 to 28.9) against PCR-confirmed SARS-CoV-2 infection, and 42.3% (95% CI, 24.9 to 55.7) against Covid-19-related hospitalization; in fully vaccinated children, vaccine effectiveness was 36.8% (95% CI, 35.3 to 38.2), 65.3% (95% CI, 62.0 to 68.3), and 82.7% (95% CI, 74.8 to 88.2), respectively.

CONCLUSIONS:

During a period when the omicron variant was predominant, BNT162b2 vaccination reduced the risks of SARS-CoV-2 infection and Covid-19-related hospitalization among children 5 to 11 years of age.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Vaccine Efficacy / BNT162 Vaccine Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Child / Child, preschool / Humans Country/Region as subject: Asia Language: English Journal: N Engl J Med Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Vaccine Efficacy / BNT162 Vaccine Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Child / Child, preschool / Humans Country/Region as subject: Asia Language: English Journal: N Engl J Med Year: 2022 Document Type: Article