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Combination Therapy With Casirivimab/Imdevimab and Remdesivir for Protracted SARS-CoV-2 Infection in B-cell-Depleted Patients.
Dioverti, M Veronica; Gaston, David C; Morris, C Paul; Huff, Carol Ann; Jain, Tania; Jones, Richard; Anders, Viki; Lederman, Howard; Saunders, Jacqueline; Mostafa, Heba H; Avery, Robin K.
  • Dioverti MV; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Gaston DC; Division of Medical Microbiology, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Morris CP; Division of Medical Microbiology, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Huff CA; Division of Hematological Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA.
  • Jain T; Division of Hematological Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA.
  • Jones R; Division of Hematological Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA.
  • Anders V; Division of Hematological Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA.
  • Lederman H; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Saunders J; Oncology Investigational Drug Service Pharmacy, Johns Hopkins Hospital, Baltimore, Maryland, USA.
  • Mostafa HH; Division of Medical Microbiology, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Avery RK; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Open Forum Infect Dis ; 9(6): ofac064, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1948416
ABSTRACT
Profoundly B-cell-depleted patients can have prolonged severe acute respiratory syndrome coronavirus 2 infections with evidence of active viral replication, due to inability to mount an adequate humoral response to clear the virus. We present 3 B-cell-depleted patients with prolonged coronavirus disease 2019 infection who were successfully treated with a combination of casirivimab/imdevimab and remdesivir.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid