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Detection of SARS-CoV-2 in COVID-19 Patient Nasal Swab Samples Using Signal Processing.
Ahmad, Mahmoud Al; Olule, Lillian J A; Meetani, Mohammed; Sheikh, Farrukh Amin; Blooshi, Rahima Al; Panicker, Neena G; Mustafa, Farah; Rizvi, Tahir A.
  • Ahmad MA; Department of Electrical EngineeringUAE University Al Ain 15551 UAE.
  • Olule LJA; Zayed Center for Health Sciences (ZCHS)UAE University Al Ain 15551 UAE.
  • Meetani M; Department of Electrical EngineeringUAE University Al Ain 15551 UAE.
  • Sheikh FA; Department of ChemistryCOS UAE University Al Ain 15551 UAE.
  • Blooshi RA; Department of MicrobiologyAl Ain Hospital Al Ain 109090 UAE.
  • Panicker NG; Department of MicrobiologyAl Ain Hospital Al Ain 109090 UAE.
  • Mustafa F; Department of Biochemistry & Molecular BiologyCMHS UAE University Al Ain 17666 UAE.
  • Rizvi TA; Department of Biochemistry and Molecular BiologyCMHS UAE University Al Ain 17666 UAE.
IEEE J Sel Top Signal Process ; 16(2): 164-174, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1948819
ABSTRACT
This work presents an opto-electrical method that measures the viral nucleocapsid protein and anti-N antibody interactions to differentiate between SARS-CoV-2 negative and positive nasal swab samples. Upon light exposure of the patient nasal swab sample mixed with the anti-N antibody, charge transfer (CT) transitions within the altered protein folds are initiated between the charged amino acids side chain moieties and the peptide backbone that play the role of donor and acceptor groups. A Figure of Merit (FOM) was introduced to correlate the relative variations of the samples with and without antibody at two different voltages. Empirically, SARS-CoV-2 in patient nasal swab samples was detected within two minutes, if an extracted FOM threshold of >1 was achieved; otherwise, the sample wasconsidered negative.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Randomized controlled trials Language: English Journal: IEEE J Sel Top Signal Process Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Randomized controlled trials Language: English Journal: IEEE J Sel Top Signal Process Year: 2022 Document Type: Article