Association between BNT162b2 vaccination and the development of delayed inflammatory reactions to hyaluronic acid-based dermal fillers-A nationwide survey.
J Cosmet Dermatol
; 21(10): 4107-4113, 2022 Oct.
Article
in English
| MEDLINE | ID: covidwho-1949600
ABSTRACT
BACKGROUND:
Delayed inflammatory reactions (DIRs) to hyaluronic acid-based dermal fillers following COVID-19 vaccination has been reported in a few anecdotal reports and small series of cases.AIM:
To evaluate the clinical characteristics, incidence, and management options relevant to BNT162b2 vaccination-associated DIR-A nationwide survey was conducted.METHODS:
An online self-administered survey was sent to physicians who actively practice tissue filler injections. The data acquired included demographic and clinical characteristics of relevant DIR cases.RESULTS:
Out of 262 responders, 20 cases with DIR following the vaccination were reported. 35% and 65% occurred shortly after the first and second vaccination dose, respectively. Overall, 65% of the DIRs appeared ≤5 days after vaccine administration and most DIRs resolved within 21 days. The filler's volume (p = 0.016) was associated with higher DIR severity, and the same tendency was noted among some filler types and locations of injection. Medical intervention was provided in 12 (60%) cases.CONCLUSION:
DIR associated with BNT162b2 vaccination is rare and tends to resolve spontaneously or with short-term medical intervention.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Dermal Fillers
/
COVID-19
/
BNT162 Vaccine
/
Hyaluronic Acid
/
Inflammation
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
J Cosmet Dermatol
Journal subject:
Dermatology
Year:
2022
Document Type:
Article
Affiliation country:
Jocd.15260
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