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A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice.
Chaparian, Ryan R; Harding, Alfred T; Hamele, Cait E; Riebe, Kristina; Karlsson, Amelia; Sempowski, Gregory D; Heaton, Nicholas S; Heaton, Brook E.
  • Chaparian RR; Department of Molecular Genetics and Microbiology, Duke Universitygrid.26009.3dgrid.471396.e School of Medicine, Durham, North Carolina, USA.
  • Harding AT; Department of Molecular Genetics and Microbiology, Duke Universitygrid.26009.3dgrid.471396.e School of Medicine, Durham, North Carolina, USA.
  • Hamele CE; Department of Molecular Genetics and Microbiology, Duke Universitygrid.26009.3dgrid.471396.e School of Medicine, Durham, North Carolina, USA.
  • Riebe K; Duke Human Vaccine Institute, Duke Universitygrid.26009.3dgrid.471396.e School of Medicine, Durham, North Carolina, USA.
  • Karlsson A; Duke Human Vaccine Institute, Duke Universitygrid.26009.3dgrid.471396.e School of Medicine, Durham, North Carolina, USA.
  • Sempowski GD; Duke Human Vaccine Institute, Duke Universitygrid.26009.3dgrid.471396.e School of Medicine, Durham, North Carolina, USA.
  • Heaton NS; Department of Molecular Genetics and Microbiology, Duke Universitygrid.26009.3dgrid.471396.e School of Medicine, Durham, North Carolina, USA.
  • Heaton BE; Duke Human Vaccine Institute, Duke Universitygrid.26009.3dgrid.471396.e School of Medicine, Durham, North Carolina, USA.
J Virol ; 96(15): e0068922, 2022 08 10.
Article in English | MEDLINE | ID: covidwho-1949995
ABSTRACT
Vaccines targeting SARS-CoV-2 have been shown to be highly effective; however, the breadth against emerging variants and the longevity of protection remains unclear. Postimmunization boosting has been shown to be beneficial for disease protection, and as new variants continue to emerge, periodic (and perhaps annual) vaccination will likely be recommended. New seasonal influenza virus vaccines currently need to be developed every year due to continual antigenic drift, an undertaking made possible by a robust global vaccine production and distribution infrastructure. To create a seasonal combination vaccine targeting both influenza viruses and SARS-CoV-2 that is also amenable to frequent reformulation, we have developed an influenza A virus (IAV) genetic platform that allows the incorporation of an immunogenic domain of the SARS-CoV-2 spike (S) protein onto IAV particles. Vaccination with this combination vaccine elicited neutralizing antibodies and provided protection from lethal challenge with both pathogens in mice. This approach may allow the leveraging of established influenza vaccine infrastructure to generate a cost-effective and scalable seasonal vaccine solution for both influenza and coronaviruses. IMPORTANCE The rapid emergence of SARS-CoV-2 variants since the onset of the pandemic has highlighted the need for both periodic vaccination "boosts" and a platform that can be rapidly reformulated to manufacture new vaccines. In this work, we report an approach that can utilize current influenza vaccine manufacturing infrastructure to generate combination vaccines capable of protecting from both influenza virus- and SARS-CoV-2-induced disease. The production of a combined influenza/SARS-CoV-2 vaccine may represent a practical solution to boost immunity to these important respiratory viruses without the increased cost and administration burden of multiple independent vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza A virus / Virion / Influenza Vaccines / Vaccines, Combined / Orthomyxoviridae Infections / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: J Virol Year: 2022 Document Type: Article Affiliation country: Jvi.00689-22

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza A virus / Virion / Influenza Vaccines / Vaccines, Combined / Orthomyxoviridae Infections / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: J Virol Year: 2022 Document Type: Article Affiliation country: Jvi.00689-22