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Persistent Maintenance of Intermediate Memory B Cells Following SARS-CoV-2 Infection and Vaccination Recall Response.
Pusnik, Jernej; König, Julia; Mai, Karola; Richter, Enrico; Zorn, Jasmin; Proksch, Hannah; Schulte, Bianca; Alter, Galit; Streeck, Hendrik.
  • Pusnik J; Institute of Virology, University Hospital Bonn, Bonn, Germany.
  • König J; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Braunschweig, Germany.
  • Mai K; Institute of Virology, University Hospital Bonn, Bonn, Germany.
  • Richter E; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Braunschweig, Germany.
  • Zorn J; Institute of Virology, University Hospital Bonn, Bonn, Germany.
  • Proksch H; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Braunschweig, Germany.
  • Schulte B; Institute of Virology, University Hospital Bonn, Bonn, Germany.
  • Alter G; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Braunschweig, Germany.
  • Streeck H; Institute of Virology, University Hospital Bonn, Bonn, Germany.
J Virol ; 96(15): e0076022, 2022 08 10.
Article in English | MEDLINE | ID: covidwho-1949996
ABSTRACT
Robust population-wide immunity will help to curb the SARS-CoV-2 pandemics. To maintain the immunity at protective levels, the quality and persistence of the immune response elicited by infection or vaccination must be determined. We analyzed the dynamics of B cell response during 12 months following SARS-CoV-2 infection on an individual level. In contrast to antibodies, memory B cells specific for the spike (S) protein persisted at high levels throughout the period. These cells efficiently secreted neutralizing antibodies and correlated with IFN-γ-secreting CD4+ T cells. Interestingly, the CD27-CD21+ intermediate memory B cell phenotype was associated with high B cell receptor avidity and the production of neutralizing antibodies. Vaccination of previously infected individuals triggered a recall response enhancing neutralizing antibody and memory B cell levels. Collectively, our findings provide a detailed insight into the longevity of SARS-CoV-2-infection-induced B cell immunity and highlight the importance of vaccination among previously infected. IMPORTANCE To efficiently maintain immunity against SARS-CoV-2 infection, we must first determine the durability of the immune response following infection or vaccination. Here, we demonstrated that, unlike antibodies, virus-specific memory B cells persist at high levels for at least 12 months postinfection and successfully respond to a secondary antigen challenge. Furthermore, we demonstrated that vaccination of previously infected individuals significantly boosters B cell immunity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Memory B Cells / Immunologic Memory Topics: Vaccines Limits: Humans Language: English Journal: J Virol Year: 2022 Document Type: Article Affiliation country: Jvi.00760-22

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Memory B Cells / Immunologic Memory Topics: Vaccines Limits: Humans Language: English Journal: J Virol Year: 2022 Document Type: Article Affiliation country: Jvi.00760-22