Gitelman's and Bartter's Syndromes: From Genetics to the Molecular Basis of Hypertension and More.
Kidney Blood Press Res
; 47(9): 556-564, 2022.
Article
in English
| MEDLINE | ID: covidwho-1950524
ABSTRACT
BACKGROUND:
Gitelman's and Bartter's syndromes (GS/BS) are rare genetic tubulopathies characterized by electrolyte imbalance and activation of the renin-angiotensin-aldosterone system (RAAS). These syndromes have intriguing biochemical and hormonal abnormalities that lead them to be protected from hypertension and cardiovascular and renal remodeling.SUMMARY:
In this review, we explore the biochemical/molecular mechanisms induced by the activation of the RAAS and its counterregulatory arm which is particularly activated in GS/BS patients, in the context of blood pressure regulation. In addition, we report our findings in the context of the COVID-19 pandemic where we observed GS/BS subjects being protected from infection. KEY MESSAGES The intracellular pathways induced by Ang II, starting from induction of oxidative stress and vasoconstriction, are crucial for the progression toward cardiovascular-renal remodeling and might be useful targets in order to reduce/halt the progression of Ang II/oxidative stress-induced cardiovascular-renal morbidity in several diseases.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Bartter Syndrome
/
Gitelman Syndrome
/
COVID-19
/
Hypertension
Limits:
Humans
Language:
English
Journal:
Kidney Blood Press Res
Journal subject:
Nephrology
Year:
2022
Document Type:
Article
Affiliation country:
000526070
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