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COVID-19 convalescent plasma.
Tobian, Aaron A R; Cohn, Claudia S; Shaz, Beth H.
  • Tobian AAR; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD.
  • Cohn CS; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN; and.
  • Shaz BH; Department of Pathology, Duke University, Durham, NC.
Blood ; 140(3): 196-207, 2022 07 21.
Article in English | MEDLINE | ID: covidwho-1951013
ABSTRACT
As the coronavirus disease (COVID-19) pandemic led to a global health crisis, there were limited treatment options and no prophylactic therapies for those exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma is quick to implement, potentially provides benefits, and has a good safety profile. The therapeutic potential of COVID-19 convalescent plasma (CCP) is likely mediated by antibodies through direct viral neutralization and Fc-dependent functions such as a phagocytosis, complement activation, and antibody-dependent cellular cytotoxicity. In the United States, CCP became one of the most common treatments with more than a half million units transfused despite limited efficacy data. More than a dozen randomized trials now demonstrate that CCP does not provide benefit for those hospitalized with moderate to severe disease. However, similar to other passive antibody therapies, CCP is beneficial for early disease when provided to elderly outpatients within 72 hours after symptom onset. Only high-titer CCP should be transfused. CCP should also be considered for immunosuppressed patients with COVID-19. CCP collected in proximity, by time and location, to the patient may be more beneficial because of SARS-CoV-2 variants. Additional randomized trial data are still accruing and should be incorporated with other trial data to optimize CCP indications.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Coronavirus / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Variants Limits: Aged / Humans Country/Region as subject: North America Language: English Journal: Blood Year: 2022 Document Type: Article Affiliation country: Blood.2021012248

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Coronavirus / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Variants Limits: Aged / Humans Country/Region as subject: North America Language: English Journal: Blood Year: 2022 Document Type: Article Affiliation country: Blood.2021012248