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COVID-19 therapies: do we see substantial progress?
Matusewicz, Lucyna; Golec, Marlena; Czogalla, Aleksander; Kuliczkowski, Kazimierz; Konka, Adam; Zembala-John, Joanna; Sikorski, Aleksander F.
  • Matusewicz L; Department of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, ul. F. Joliot Curie 14a, 50-383, Wroclaw, Poland.
  • Golec M; Silesian Park of Medical Technology Kardio-Med Silesia, ul. M. Curie-Sklodowskiej 10c, 41-800, Zabrze, Poland.
  • Czogalla A; Department of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, ul. F. Joliot Curie 14a, 50-383, Wroclaw, Poland.
  • Kuliczkowski K; Silesian Park of Medical Technology Kardio-Med Silesia, ul. M. Curie-Sklodowskiej 10c, 41-800, Zabrze, Poland.
  • Konka A; Silesian Park of Medical Technology Kardio-Med Silesia, ul. M. Curie-Sklodowskiej 10c, 41-800, Zabrze, Poland.
  • Zembala-John J; Chair and Department of Medicine and Environmental Epidemiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, H. Jordana 19, 41-800, Zabrze, Poland.
  • Sikorski AF; Acellmed Ltd., M. Curie-Sklodowskiej 10C, 41-800, Zabrze, Poland.
Cell Mol Biol Lett ; 27(1): 42, 2022 May 31.
Article in English | MEDLINE | ID: covidwho-1951044
ABSTRACT
The appearance of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its spread all over the world is the cause of the coronavirus disease 2019 (COVID-19) pandemic, which has recently resulted in almost 400 million confirmed cases and 6 million deaths, not to mention unknown long-term or persistent side effects in convalescent individuals. In this short review, we discuss approaches to treat COVID-19 that are based on current knowledge of the mechanisms of viral cell receptor recognition, virus-host membrane fusion, and inhibition of viral RNA and viral assembly. Despite enormous progress in antiviral therapy and prevention, new effective therapies are still in great demand.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: English Journal: Cell Mol Biol Lett Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: S11658-022-00341-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: English Journal: Cell Mol Biol Lett Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: S11658-022-00341-9