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Delayed-onset Organizing Pneumonia Emerging after Recovery from Coronavirus Disease 2019: A Report of Three Cases Diagnosed Using Transbronchial Cryobiopsy and a Review of the Literature.
Nakakubo, Sho; Kamada, Keisuke; Yamashita, Yu; Nakamura, Junichi; Matsumoto, Munehiro; Horii, Hiroshi; Sato, Kazuki; Morinaga, Daisuke; Suzuki, Masaru; Okazaki, Nanase; Takakuwa, Emi; Matsuno, Yoshihiro; Konno, Satoshi.
  • Nakakubo S; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Kamada K; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Yamashita Y; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Nakamura J; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Matsumoto M; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Horii H; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Sato K; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Morinaga D; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Suzuki M; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
  • Okazaki N; Department of Surgical Pathology, Hokkaido University Hospital, Japan.
  • Takakuwa E; Department of Surgical Pathology, Hokkaido University Hospital, Japan.
  • Matsuno Y; Department of Surgical Pathology, Hokkaido University Hospital, Japan.
  • Konno S; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Intern Med ; 61(9): 1403-1410, 2022 May 01.
Article in English | MEDLINE | ID: covidwho-1951859
ABSTRACT
We present three cases with an atypical clinical course of organizing pneumonia (OP) secondary to coronavirus disease 2019 (COVID-19). Three patients were discharged with satisfactory improvement after standard steroid therapy for COVID-19. Shortly after the completion of treatment, the patients experienced a flare-up of symptoms. Imaging results showed new lesions in the lungs. Transbronchial lung cryobiopsy showed histological findings consistent with OP in all cases. Steroids were administered, and a good therapeutic response was observed. This report is the first to describe pathologically confirmed OP that developed after recovery from COVID-19. Careful follow-up is advisable for patients who have recovered from COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Cryptogenic Organizing Pneumonia / COVID-19 Type of study: Case report / Cohort study / Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2022 Document Type: Article Affiliation country: Internalmedicine.9016-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Cryptogenic Organizing Pneumonia / COVID-19 Type of study: Case report / Cohort study / Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2022 Document Type: Article Affiliation country: Internalmedicine.9016-21