Your browser doesn't support javascript.
The Effect of Inactivated SARS-CoV-2 Vaccines on TRAB in Graves' Disease.
Huang, LingHong; Jiang, ZhengRong; Zhou, JingXiong; Chen, YuPing; Huang, HuiBin.
  • Huang L; The Second Clinical Medical College of Fujian Medical University, Quanzhou, China.
  • Jiang Z; Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
  • Zhou J; Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
  • Chen Y; Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
  • Huang H; Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Front Endocrinol (Lausanne) ; 13: 835880, 2022.
Article in English | MEDLINE | ID: covidwho-1952295
ABSTRACT

Background:

The ongoing coronavirus disease 2019 (COVID-19) pandemic has forced the development of vaccines. Reports have suggested that vaccines play a role in inducing autoimmune diseases (AIDs). Scattered cases have reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may promote thyroid disease, including Graves' disease (GD). However, the effect of inactivated SARS-CoV-2 vaccine on GD remains unclear. The aim of the present study was to investigate the response of thyrotropin receptor antibody (TRAB) to inactivated SARS-COV-2 vaccines.

Methods:

We conducted a retrospective study to observe the differences in thyroid function and TRAB trends between pre-vaccination (n=412) and post-vaccination (n=231) groups at an interval of 2 months. We then retrospectively observed the differences in serum thyroid function and TRAB levels at 3 months before (n=280), 1 month before (n=294), 1 month after (n=306), and 3 months after (n=250) vaccination. Subsequently, 173 GD patients who were not vaccinated with inactivated SARS-COV-2 vaccines were selected for a prospective study. Thyroid function and TRAB assessment were performed before 3 and 1 months and 1 and 3 months after the first dose of vaccination and were then compared by repeated measures ANOVA to explore their dynamic changes.

Results:

A retrospective study preliminarily observed that the trend of TRAB post-vaccination was opposite of that pre-vaccination (p=0.000), serum TRAB levels decreased before vaccination and increased after vaccination. In this prospective study, repeated measures ANOVA indicated significant differences in serum FT3 (p=0.000), FT4 (p=0.000), TSH (p=0.000), and TRAB (p=0.000) levels at different time points before and after vaccination. Serum TRAB levels showed dynamic changes that decreased significantly at 1 month before vaccination (p=0.000), no significant differences at 1 month after vaccination (p=0.583), and reflected an upward trend at 3 months after vaccination (p=0.034). Serum FT3 and FT4 levels showed similar trends to serum TRAB levels before and after vaccination. Instead, the serum TSH levels showed a continuous upward trend over time.

Conclusion:

Based on the results obtained in both retrospective and prospective studies, we concluded that serum TRAB levels decreased less after inactivated SARS-CoV-2 vaccination and showed an upward trend, which may be related to humoral immunity induced by vaccination.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / Graves Disease / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Front Endocrinol (Lausanne) Year: 2022 Document Type: Article Affiliation country: Fendo.2022.835880

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / Graves Disease / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Front Endocrinol (Lausanne) Year: 2022 Document Type: Article Affiliation country: Fendo.2022.835880