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Atypical Antibody Dynamics During Human Coronavirus HKU1 Infections.
Sechan, Ferdyansyah; Grobben, Marloes; Edridge, Arthur W D; Jebbink, Maarten F; Loens, Katherine; Ieven, Margareta; Goossens, Herman; van Hemert-Glaubitz, Susan; van Gils, Marit J; van der Hoek, Lia.
  • Sechan F; Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
  • Grobben M; Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
  • Edridge AWD; Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
  • Jebbink MF; Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
  • Loens K; Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
  • Ieven M; Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
  • Goossens H; Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
  • van Hemert-Glaubitz S; Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
  • van Gils MJ; Department of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerpen, Belgium.
  • van der Hoek L; Department of Microbiology, University Hospital Antwerp, Edegem, Belgium.
Front Microbiol ; 13: 853410, 2022.
Article in English | MEDLINE | ID: covidwho-1952413
ABSTRACT
Human coronavirus HKU1 (HCoV-HKU1) is one of the four endemic coronaviruses. It has been suggested that there is a difference in incidence, with PCR-confirmed HCoV-NL63 and HCoV-OC43 infections occurring more commonly, whereas HCoV-HKU1 is the least seen. Lower incidence of HCoV-HKU1 infection has also been observed in serological studies. The current study aimed to investigate antibody dynamics during PCR-confirmed HCoV-HKU1 infections using serum collected during infection and 1 month later. We expressed a new HCoV-HKU1 antigen consisting of both the linker and carboxy-terminal domain of the viral nucleocapsid protein and implemented it in ELISA. We also applied a spike-based Luminex assay on serum samples from PCR-confirmed infections by the four endemic HCoVs. At least half of HCoV-HKU1-infected subjects consistently showed no antibody rise via either assay, and some subjects even exhibited substantial antibody decline. Investigation of self-reported symptoms revealed that HCoV-HKU1-infected subjects rated their illness milder than subjects infected by other HCoVs. In conclusion, HCoV-HKU1 infections reported in this study displayed atypical antibody dynamics and milder symptoms when compared to the other endemic HCoVs.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Journal: Front Microbiol Year: 2022 Document Type: Article Affiliation country: Fmicb.2022.853410

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Journal: Front Microbiol Year: 2022 Document Type: Article Affiliation country: Fmicb.2022.853410