Comparison between Suspected and Confirmed COVID-19 Respiratory Patients: What Is beyond the PCR Test.
J Clin Med
; 11(11)2022 May 25.
Article
in English
| MEDLINE | ID: covidwho-1953596
ABSTRACT
COVID-19 modified the healthcare system. Nasal-pharyngeal swab (NPS), with real-time reverse transcriptase-polymerase (PCR), is the gold standard for the diagnosis; however, there are difficulties related to the procedure that may postpone it. The study aims to evaluate whether other elements than the PCR-NPS are reliable and confirm the diagnosis of COVID-19. This is a cross-sectional study on data from the Lung Unit of Pavia (confirmed) and at the Emergency Unit of Palermo (suspected). COVID-19 was confirmed by positive NPS, suspected tested negative. We compared clinical, laboratory and radiological variables and performed Logistic regression to estimate which variables increased the risk of COVID-19. The derived ROC-AUCcurve, assessed the accuracy of the model to distinguish between COVID-19 suspected and confirmed. We selected 50 confirmed and 103 suspected cases. High Reactive C-Protein (OR 1.02; CI95% 0.11-1.02), suggestive CT-images (OR 11.43; CI95% 3.01-43.3), dyspnea (OR 10.48; CI95% 2.08-52.7) and respiratory failure (OR 5.84; CI95% 1.73-19.75) increased the risk of COVID-19, whereas pleural effusion decreased the risk (OR 0.15; CI95% 0.04-0.63). ROC confirmed the discriminative role of these variables between suspected and confirmed COVID-19 (AUC 0.91). Clinical, laboratory and imaging features predict the diagnosis of COVID-19, independently from the NPS result.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Jcm11112993
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