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Comparison between Suspected and Confirmed COVID-19 Respiratory Patients: What Is beyond the PCR Test.
Principe, Stefania; Grosso, Amelia; Benfante, Alida; Albicini, Federica; Battaglia, Salvatore; Gini, Erica; Amata, Marta; Piccionello, Ilaria; Corsico, Angelo Guido; Scichilone, Nicola.
  • Principe S; Department of Pulmonology-Palermo (PA) (Italy), AOUP Policlinico Paolo Giaccone, University of Palermo, 90127 Palermo, Italy.
  • Grosso A; Department of Respiratory Medicine-Amsterdam, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
  • Benfante A; Department of Pulmonology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
  • Albicini F; Department of Pulmonology-Palermo (PA) (Italy), AOUP Policlinico Paolo Giaccone, University of Palermo, 90127 Palermo, Italy.
  • Battaglia S; Department of Pulmonology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
  • Gini E; Department of Pulmonology-Palermo (PA) (Italy), AOUP Policlinico Paolo Giaccone, University of Palermo, 90127 Palermo, Italy.
  • Amata M; Department of Pulmonology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
  • Piccionello I; Department of Pulmonology-Palermo (PA) (Italy), AOUP Policlinico Paolo Giaccone, University of Palermo, 90127 Palermo, Italy.
  • Corsico AG; Department of Pulmonology-Palermo (PA) (Italy), AOUP Policlinico Paolo Giaccone, University of Palermo, 90127 Palermo, Italy.
  • Scichilone N; Department of Pulmonology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
J Clin Med ; 11(11)2022 May 25.
Article in English | MEDLINE | ID: covidwho-1953596
ABSTRACT
COVID-19 modified the healthcare system. Nasal-pharyngeal swab (NPS), with real-time reverse transcriptase-polymerase (PCR), is the gold standard for the diagnosis; however, there are difficulties related to the procedure that may postpone it. The study aims to evaluate whether other elements than the PCR-NPS are reliable and confirm the diagnosis of COVID-19. This is a cross-sectional study on data from the Lung Unit of Pavia (confirmed) and at the Emergency Unit of Palermo (suspected). COVID-19 was confirmed by positive NPS, suspected tested negative. We compared clinical, laboratory and radiological variables and performed Logistic regression to estimate which variables increased the risk of COVID-19. The derived ROC-AUCcurve, assessed the accuracy of the model to distinguish between COVID-19 suspected and confirmed. We selected 50 confirmed and 103 suspected cases. High Reactive C-Protein (OR 1.02; CI95% 0.11-1.02), suggestive CT-images (OR 11.43; CI95% 3.01-43.3), dyspnea (OR 10.48; CI95% 2.08-52.7) and respiratory failure (OR 5.84; CI95% 1.73-19.75) increased the risk of COVID-19, whereas pleural effusion decreased the risk (OR 0.15; CI95% 0.04-0.63). ROC confirmed the discriminative role of these variables between suspected and confirmed COVID-19 (AUC 0.91). Clinical, laboratory and imaging features predict the diagnosis of COVID-19, independently from the NPS result.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11112993

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11112993