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Synthesis and Antiviral Properties against SARS-CoV-2 of Epoxybenzooxocino[4,3-b]Pyridine Derivatives.
Stalinskaya, Alena L; Martynenko, Nadezhda V; Shulgau, Zarina T; Shustov, Alexandr V; Keyer, Viktoriya V; Kulakov, Ivan V.
  • Stalinskaya AL; Institute of Chemistry, Tyumen State University, 15a Perekopskaya St., 625003 Tyumen, Russia.
  • Martynenko NV; Institute of Chemistry, Tyumen State University, 15a Perekopskaya St., 625003 Tyumen, Russia.
  • Shulgau ZT; National Center for Biotechnology, 13/5 Kurgalzhynskoe road, Nur-Sultan 010000, Kazakhstan.
  • Shustov AV; National Center for Biotechnology, 13/5 Kurgalzhynskoe road, Nur-Sultan 010000, Kazakhstan.
  • Keyer VV; National Center for Biotechnology, 13/5 Kurgalzhynskoe road, Nur-Sultan 010000, Kazakhstan.
  • Kulakov IV; Institute of Chemistry, Tyumen State University, 15a Perekopskaya St., 625003 Tyumen, Russia.
Molecules ; 27(12)2022 Jun 09.
Article in English | MEDLINE | ID: covidwho-1953759
ABSTRACT
The COVID-19 pandemic is ongoing as of mid-2022 and requires the development of new therapeutic drugs, because the existing clinically approved drugs are limited. In this work, seven derivatives of epoxybenzooxocinopyridine were synthesized and tested for the ability to inhibit the replication of the SARS-CoV-2 virus in cell cultures. Among the described compounds, six were not able to suppress the SARS-CoV-2 virus' replication. One compound, which is a derivative of epoxybenzooxocinopyridine with an attached side group of 3,4-dihydroquinoxalin-2-one, demonstrated antiviral activity comparable to that of one pharmaceutical drug. The described compound is a prospective lead substance, because the half-maximal effective concentration is 2.23 µg/µL, which is within a pharmacologically achievable range.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27123701

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27123701