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Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus.
Batot, Cédric; Chea, Maryane; Zeidan, Sinead; Mongin, Marie; Pop, Gabriel; Mazoyer, Julie; Degos, Bertrand.
  • Batot C; Neurology Unit, AP-HP, Avicenne University Hospital, Sorbonne Paris Nord, Bobigny, France.
  • Chea M; Neurology Unit, AP-HP, Avicenne University Hospital, Sorbonne Paris Nord, Bobigny, France.
  • Zeidan S; Neurology Unit, AP-HP, Avicenne University Hospital, Sorbonne Paris Nord, Bobigny, France.
  • Mongin M; Neurology Unit, AP-HP, Avicenne University Hospital, Sorbonne Paris Nord, Bobigny, France.
  • Pop G; Department of Nuclear Medicine Unit, AP-HP, Avicenne University Hospital, Sorbonne Paris Nord, Bobigny, France.
  • Mazoyer J; Neurology Unit, AP-HP, Avicenne University Hospital, Sorbonne Paris Nord, Bobigny, France.
  • Degos B; Neurology Unit, AP-HP, Avicenne University Hospital, Sorbonne Paris Nord, Bobigny, France.
Tremor Other Hyperkinet Mov (N Y) ; 12: 16, 2022.
Article in English | MEDLINE | ID: covidwho-1954609
ABSTRACT

Background:

Hemichorea-hemiballismus is a rare hyperkinetic movement disorder. Case Report A 90-year-old male developed left hemichorea-hemiballismus after his second dose of the Pfizer-BioNTech COVID-19 vaccine. A wide range of investigations including magnetic resonance imaging did not reveal an alternative cause. [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed increases in right putamen fixation compared to the left side. The patient showed significant improvement after five days of intravenous corticosteroids, with a normal FDG-PET.

Discussion:

This hemichorea-hemiballismus case shows dynamic restoration of putamen metabolism mirroring clinical evolution after administration of corticosteroids, suggesting an autoimmune COVID-19 vaccine-induced reaction.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chorea / Dyskinesias / COVID-19 Type of study: Case report / Cohort study / Prognostic study Topics: Vaccines Limits: Humans / Male Language: English Journal: Tremor Other Hyperkinet Mov (N Y) Year: 2022 Document Type: Article Affiliation country: Tohm.688

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chorea / Dyskinesias / COVID-19 Type of study: Case report / Cohort study / Prognostic study Topics: Vaccines Limits: Humans / Male Language: English Journal: Tremor Other Hyperkinet Mov (N Y) Year: 2022 Document Type: Article Affiliation country: Tohm.688