Gastrointestinal injury in COVID-19.

ABSTRACT

The literature review summarizes the main aspects of the impact of SARS-CoV-2 on the gastrointestinal tract, which must be taken into account during a difficult epidemiological situation, and shows the main clinical and functional changes that affect the condition of patients and the activities of the healthcare system. The clinical manifestations caused by the action of SARS-CoV-2 on the organs of the gastrointestinal tract are described in detail. Clinical and laboratory methods established the fact of the development of a multi-inflammatory syndrome, which determines the systemic profile of the lesion and determines the nature and severity of the course of the disease, its complications and outcome. The histological picture of the lesion of the digestive system by the virus is described. The necessity of further studies of the mechanisms of interaction of the virus with the cells of the intestine and the immune system in order to develop methods for early diagnosis, effective treatment and prevention of complications of a new coronavirus infection is substantiated. The E-library, MedLine, National Center for Biotechnology Information databases were used to search for literature sources. (English) [ FROM AUTHOR] В обзоре литературы обобщены основные аспекты влияния SARS-CoV-2 на желудочно-кишечный тракт и связанные с этим особенности организации медицинской помощи, которые необходимо учитывать во время сложной эпидемиологической ситуации. Приведены основные клинико-функциональные изменения в состоянии пациентов. Клинико-лабораторными методами установлен факт развития мультивоспалительного синдрома, обусловливающего системный профиль поражения, определяющего характер и тяжесть течения болезни, ее осложнения и исход. Описана гистологическая картина поражения вирусом органов пищеварения. Обоснована необходимость дальнейших исследований механизмов взаимодействия вируса с клетками кишечника и иммунной системы для разработки методов ранней диагностики, эффективного лечения и профилактики осложнений новой коронавирусной инфекции. Для поиска источников литературы использованы базы данных e-Library, MedLine, National Center for Biotechnology Information. (Russian) [ FROM AUTHOR] Copyright of Profilakticheskaya Meditsina is the property of Media Sphere Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)